PBN-PVT projections modulate negative affective states in mice

Zhu，Ya Bing1; Wang，Yan1; Hua，Xiao Xiao2; Xu，Ling1; Liu，Ming Zhe3; Zhang，Rui1; Liu，Peng Fei1; Li，Jin Bao1; Zhang，Ling2; Mu，Di4

2022-02-01

10.7554/ELIFE.68372

eLife   影响因子和分区

2050-084X

2050-084X

Long-lasting negative affections dampen enthusiasm for life, and dealing with negative affective states is essential for individual survival. The parabrachial nucleus (PBN) and thalamic paraventricular nucleus (PVT) are critical for modulating affective states in mice. However, the functional roles of PBN-PVT projections in modulating affective states remain elusive. Here, we show that PBN neurons send dense projection fibers to the PVT and form direct excitatory synapses with PVT neurons. Activation of the PBN-PVT pathway induces robust behaviors associated with negative affective states without affecting nociceptive behaviors. Inhibition of the PBN-PVT pathway reduces aversion-like and fear-like behaviors. Furthermore, the PVT neurons innervated by the PBN are activated by aversive stimulation, and activation of PBN-PVT projections enhances the neuronal activity of PVT neurons in response to the aversive stimulus. Consistently, activation of PVT neurons that received PBN-PVT projections induces anxiety-like behaviors. Thus, our study indicates that PBN-PVT projections modulate negative affective states in mice.

Affective states Anxiety Aversion Parabrachial nucleus (PBN) Thalamic paraventricular nucleus (PVT)

SCI

英语

通讯

National Natural Science Foundation of China[31900717,31571086] ; Shanghai Sailing Program[19YF1438700] ; Young Elite Scientists Sponsorship Program of China Association for Science and Technology[2019QNRC001] ; Shanghai Natural Science Foundation[21ZR1468600]

Life Sciences & Biomedicine - Other Topics

Biology

WOS:000777837200001

eLIFE SCIENCES PUBL LTD

2-s2.0-85127327945

Scopus

1.Department of Anesthesiology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,201620,China
2.The First Rehabilitation Hospital of Shanghai,Tongji University School of Medicine,Shanghai,200090,China
3.Department of Respiratory,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510120,China
4.SUSTech Center for Pain Medicine,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China

Zhu，Ya Bing,Wang，Yan,Hua，Xiao Xiao,et al. PBN-PVT projections modulate negative affective states in mice[J]. eLife,2022,11.

Zhu，Ya Bing.,Wang，Yan.,Hua，Xiao Xiao.,Xu，Ling.,Liu，Ming Zhe.,...&Mu，Di.(2022).PBN-PVT projections modulate negative affective states in mice.eLife,11.

Zhu，Ya Bing,et al."PBN-PVT projections modulate negative affective states in mice".eLife 11(2022).