Nanocomposite hydrogels for biomedical applications

Huang，Shanghui1; Hong，Xiangqian2,3; Zhao，Mingyi4; Liu，Nanbo4; Liu，Huiling1; Zhao，Jun3,5; Shao，Longquan6; Xue，Wei1; Zhang，Han2; Zhu，Ping4; Guo，Rui1

2022

10.1002/btm2.10315

Bioengineering and Translational Medicine   影响因子和分区

2380-6761

Nanomaterials' unique structures at the nanometer level determine their incredible functions, and based on this, they can be widely used in the field of nanomedicine. However, nanomaterials do possess disadvantages that cannot be ignored, such as burst release, rapid elimination, and poor bioadhesion. Hydrogels are scaffolds with three-dimensional structures, and they exhibit good biocompatibility and drug release capacity. Hydrogels are also associated with disadvantages for biomedical applications such as poor anti-tumor capability, weak bioimaging capability, limited responsiveness, and so on. Incorporating nanomaterials into the 3D hydrogel network through physical or chemical covalent action may be an effective method to avoid their disadvantages. In nanocomposite hydrogel systems, multifunctional nanomaterials often work as the function core, giving the hydrogels a variety of properties (such as photo-thermal conversion, magnetothermal conversion, conductivity, targeting tumor, etc.). While, hydrogels can effectively improve the retention effect of nanomaterials and make the nanoparticles have good plasticity to adapt to various biomedical applications (such as various biosensors). Nanocomposite hydrogel systems have broad application prospects in biomedicine. In this review, we comprehensively summarize and discuss the most recent advances of nanomaterials composite hydrogels in biomedicine, including drug and cell delivery, cancer treatment, tissue regeneration, biosensing, and bioimaging, and we also briefly discussed the current situation of their commoditization in biomedicine.

bioimaging biosensing cancer treatment drug and cell delivery nanocomposite hydrogels tissue regeneration

SCI ; EI

英语

其他

Science and Technology Project of Guangdong Province[2020B1111560001] ; Key Areas and Development Program of Guangzhou[202007020006,202103030003] ; National Key Research and Development Program of China["2018YFA0108700","2017YFA0105602"] ; NSFC Projects of International Cooperation and Exchanges[81720108004] ; International Science and Technology Cooperation Project of Huangpu District/Guangzhou Development District["2019GH11","2020GH14"]

Biotechnology & Applied Microbiology ; Engineering ; Pharmacology & Pharmacy

Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Pharmacology & Pharmacy

WOS:000779595300001

WILEY

2-s2.0-85127683968

Scopus

1.Key Laboratory of Biomaterials of Guangdong Higher Education Institutes,Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development,Department of Biomedical Engineering,Jinan University,Guangzhou,China
2.Institute of Microscale Optoelectronics,Collaborative Innovation Centre for Optoelectronic Science & Technology,International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education,Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology,Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ),College of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen,China
3.Shenzhen Eye Hospital,Shenzhen Eye Institute,Shenzhen Eye Hospital affiliated to Jinan University,School of Optometry,Shenzhen University,Shenzhen,China
4.Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,China
5.Department of Ophthalmology,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China
6.Stomatological Hospital,Southern Medical University,Guangzhou,China

Huang，Shanghui,Hong，Xiangqian,Zhao，Mingyi,et al. Nanocomposite hydrogels for biomedical applications[J]. Bioengineering and Translational Medicine,2022.

Huang，Shanghui.,Hong，Xiangqian.,Zhao，Mingyi.,Liu，Nanbo.,Liu，Huiling.,...&Guo，Rui.(2022).Nanocomposite hydrogels for biomedical applications.Bioengineering and Translational Medicine.

Huang，Shanghui,et al."Nanocomposite hydrogels for biomedical applications".Bioengineering and Translational Medicine (2022).