Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing

Chen，Xingmei1; Zhang，Jun1; Chen，Guangda1; Xue，Yu1; Zhang，Jiajun1; Liang，Xiangyu1; Lei，Iek Man1; Lin，Jingsen1; Xu，Ben Bin2; Liu，Ji1,3,4

2022

10.1002/adfm.202202285

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

Hydrogel bioadhesives have emerged as one of the most promising alternatives to sutures and staples for wound sealing and repairing, owing to their unique advantages in biocompatibility, mechanical compliance, and minimally invasive manipulation. However, only a few hydrogel bioadhesives have been successfully used for gastric perforation repair, due to their undesirable swelling when in direct contact with extremely acidic gastric fluids, and are thereby accompanied by a gradually deteriorating adhesion performance. Herein, an acid-tolerant hydrogel (ATGel) bioadhesive is developed, which integrates two distinct components, an acid-tolerant hydrogel substrate and an adhesive polymer brush layer. The ATGel bioadhesive can form instant, atraumatic, fluid-tight, and sutureless sealing of gastric perforation, and enable robust biointerfaces in direct contact with gastric fluids, addressing the key limitations with sutures and commercially-available tissue adhesives. Moreover, in vivo investigation on gastric perforation of rat model validates the proposed acid-tolerant bioadhesion, and identifies the mechanisms for accelerated gastric perforation repair through alleviated inflammation, which suppresses fibrosis and enhances angiogenesis.

biointerface gastric perforation hydrogel bioadhesives robustness swelling resistance

SCI ; EI

英语

NI论文

第一 ; 通讯

Shenzhen municipal government[Y01336223] ; SUSTech["Y01346002","Y01336123"] ; Science, Technology and Innovation Commission of Shenzhen Municipality[ZDSYS20200811143601004] ; Basic and Applied Basic Research Foundation of Guangdong Province[2020A1515110288] ; Basic Research Program of Shenzhen[JCYJ20210324105211032]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000779573100001

WILEY-V C H VERLAG GMBH

20221511942156

Acid resistance ; Adhesives ; Biocompatibility ; Repair

Immunology:461.9.1 ; Colloid Chemistry:801.3 ; Chemical Reactions:802.2 ; Chemical Products Generally:804 ; Maintenance:913.5

MATERIALS SCIENCE

2-s2.0-85127647675

Scopus

1.Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Smart Materials and Surfaces Laboratory,Faculty of Engineering and Environment,Northumbria University,Newcastle upon Tyne,NE1 8ST,United Kingdom
3.Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems,Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,518055,China
4.Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities,Southern University of Science and Technology,Shenzhen,518055,China

Chen，Xingmei,Zhang，Jun,Chen，Guangda,et al. Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing[J]. ADVANCED FUNCTIONAL MATERIALS,2022,32.

Chen，Xingmei.,Zhang，Jun.,Chen，Guangda.,Xue，Yu.,Zhang，Jiajun.,...&Liu，Ji.(2022).Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing.ADVANCED FUNCTIONAL MATERIALS,32.

Chen，Xingmei,et al."Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing".ADVANCED FUNCTIONAL MATERIALS 32(2022).