Anti-Inflammatory and Repairing Effects of Mesoporous Silica-Loaded Metronidazole Composite Hydrogel on Human Dental Pulp Cells

Wang，Wei1; Wang，Xixi2; Li，Luyang2; Liu，Ying2

2022

10.1155/2022/6774075

Journal of Healthcare Engineering   影响因子和分区

2040-2295

2040-2309

In order to test an effective biopolymer scaffold in promoting the growth of human dental pulp stem cells (HDPSCs), mesoporous silica @ hydrogel (MSN@Gel) nanocomposites are invented as a new type of biopolymer scaffold for HDPSCs proliferation in this paper. The expression levels of alkaline phosphatase (ALP), dentin matrix protein 1 (DMP1), and dentin sialophosphoprotein (DSPP) are significantly increased in the MSN@Gel group so as to better repair damaged dentin. In order to inhibit the proliferation of bacteria in the dental pulp, metronidazole (MTR) is loaded into MSN. The study found that MSN could effectively prolong the half-life of MTR by 1.75 times, and the viability of HDPSCs could be better maintained in the MSN-MTR@Gel group so as to better promote its proliferation to repair pulpitis. However, with the increase of the MTR concentration, its proliferation effect on HDPSCs decreased gradually, and the proliferation effect is the best in 10 μmol/L. Therefore, the MSN-MTR@Gel scaffold is expected to become an effective method for pulpitis therapy in the future.

SCI ; EI

英语

第一

Health Care Sciences & Services

Health Care Sciences & Services

WOS:000799201800012

HINDAWI LTD

2-s2.0-85127465657

Scopus

1.Oral Medical Center,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China
2.Department of Stomatology,The Affiliated Jiangning Hospital,Nanjing Medical University,Nanjing,211100,China

Wang，Wei,Wang，Xixi,Li，Luyang,et al. Anti-Inflammatory and Repairing Effects of Mesoporous Silica-Loaded Metronidazole Composite Hydrogel on Human Dental Pulp Cells[J]. Journal of Healthcare Engineering,2022,2022.

Wang，Wei,Wang，Xixi,Li，Luyang,&Liu，Ying.(2022).Anti-Inflammatory and Repairing Effects of Mesoporous Silica-Loaded Metronidazole Composite Hydrogel on Human Dental Pulp Cells.Journal of Healthcare Engineering,2022.

Wang，Wei,et al."Anti-Inflammatory and Repairing Effects of Mesoporous Silica-Loaded Metronidazole Composite Hydrogel on Human Dental Pulp Cells".Journal of Healthcare Engineering 2022(2022).