| 题名 | Anti-Inflammatory and Repairing Effects of Mesoporous Silica-Loaded Metronidazole Composite Hydrogel on Human Dental Pulp Cells |
| 作者 | |
| 通讯作者 | Liu，Ying |
| 发表日期 | 2022
|
| DOI | |
| 发表期刊 | |
| ISSN | 2040-2295
|
| EISSN | 2040-2309
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| 卷号 | 2022 |
| 摘要 | In order to test an effective biopolymer scaffold in promoting the growth of human dental pulp stem cells (HDPSCs), mesoporous silica @ hydrogel (MSN@Gel) nanocomposites are invented as a new type of biopolymer scaffold for HDPSCs proliferation in this paper. The expression levels of alkaline phosphatase (ALP), dentin matrix protein 1 (DMP1), and dentin sialophosphoprotein (DSPP) are significantly increased in the MSN@Gel group so as to better repair damaged dentin. In order to inhibit the proliferation of bacteria in the dental pulp, metronidazole (MTR) is loaded into MSN. The study found that MSN could effectively prolong the half-life of MTR by 1.75 times, and the viability of HDPSCs could be better maintained in the MSN-MTR@Gel group so as to better promote its proliferation to repair pulpitis. However, with the increase of the MTR concentration, its proliferation effect on HDPSCs decreased gradually, and the proliferation effect is the best in 10 μmol/L. Therefore, the MSN-MTR@Gel scaffold is expected to become an effective method for pulpitis therapy in the future. |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 第一
|
| WOS研究方向 | Health Care Sciences & Services
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| WOS类目 | Health Care Sciences & Services
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| WOS记录号 | WOS:000799201800012
|
| 出版者 | |
| Scopus记录号 | 2-s2.0-85127465657
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| 来源库 | Scopus
|
| 引用统计 |
被引频次[WOS]：7
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/329647 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Oral Medical Center,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China 2.Department of Stomatology,The Affiliated Jiangning Hospital,Nanjing Medical University,Nanjing,211100,China |
| 第一作者单位 | 南方科技大学第一附属医院 |
| 第一作者的第一单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Wang，Wei,Wang，Xixi,Li，Luyang,et al. Anti-Inflammatory and Repairing Effects of Mesoporous Silica-Loaded Metronidazole Composite Hydrogel on Human Dental Pulp Cells[J]. Journal of Healthcare Engineering,2022,2022.
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| APA |
Wang，Wei,Wang，Xixi,Li，Luyang,&Liu，Ying.(2022).Anti-Inflammatory and Repairing Effects of Mesoporous Silica-Loaded Metronidazole Composite Hydrogel on Human Dental Pulp Cells.Journal of Healthcare Engineering,2022.
|
| MLA |
Wang，Wei,et al."Anti-Inflammatory and Repairing Effects of Mesoporous Silica-Loaded Metronidazole Composite Hydrogel on Human Dental Pulp Cells".Journal of Healthcare Engineering 2022(2022).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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