| 题名 | Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms |
| 作者 | |
| 通讯作者 | Shao，Zengwu; Xiao，Guozhi |
| 发表日期 | 2022
|
| DOI | |
| 发表期刊 | |
| ISSN | 1838-7640
|
| EISSN | 1838-7640
|
| 卷号 | 12期号:6页码:2722-2740 |
| 摘要 | Aging is a natural process, which plays a critical role in the pathogenesis of a variety of diseases, i.e., aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease, cardiovascular diseases, cancers, obesity and other metabolic abnormalities. Metformin, the most widely used antidiabetic drug, has been reported to delay aging and display protective effect on attenuating progression of various aging-related diseases by impacting key hallmark events of aging, including dysregulated nutrient sensing, loss of proteostasis, mitochondrial dysfunction, altered intercellular communication, telomere attrition, genomic instability, epigenetic alterations, stem cell exhaustion and cellular senescence. In this review, we provide updated information and knowledge on applications of metformin in prevention and treatment of aging and aging-related diseases. We focus our discussions on the roles and underlying mechanisms of metformin in modulating aging and treating aging-related diseases. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
|
| 重要成果 | ESI高被引
|
| 学校署名 | 通讯
|
| 资助项目 | National Key Research and Development Program of China[2019YFA0906004]
; National Natural Science Foundation of China[81991513,81870532]
; Guangdong Provincial Science and Technology Innovation Council[2017B030301018]
|
| WOS研究方向 | Research & Experimental Medicine
|
| WOS类目 | Medicine, Research & Experimental
|
| WOS记录号 | WOS:000777626900017
|
| 出版者 | |
| Scopus记录号 | 2-s2.0-85127007512
|
| 来源库 | Scopus
|
| 引用统计 |
被引频次[WOS]：79
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/329655 |
| 专题 | 南方科技大学医学院_生物化学系 南方科技大学医学院 |
| 作者单位 | 1.Department of Orthopaedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China 2.Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Shenzhen Key Laboratory of Cell Microenvironment,Shenzhen,518055,China 3.Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology,Department of Spine Surgery,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou,510080,China |
| 第一作者单位 | 生物化学系; 南方科技大学医学院 |
| 通讯作者单位 | 生物化学系; 南方科技大学医学院 |
| 推荐引用方式 GB/T 7714 |
Chen，Sheng,Gan，Donghao,Lin，Sixiong,et al. Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms[J]. Theranostics,2022,12(6):2722-2740.
|
| APA |
Chen，Sheng.,Gan，Donghao.,Lin，Sixiong.,Zhong，Yiming.,Chen，Mingjue.,...&Xiao，Guozhi.(2022).Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms.Theranostics,12(6),2722-2740.
|
| MLA |
Chen，Sheng,et al."Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms".Theranostics 12.6(2022):2722-2740.
|
| 条目包含的文件 | 条目无相关文件。 | |||||
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