High Spatial and Temporal Resolution NIR-IIb Gastrointestinal Imaging in Mice

Mi，Chao1; Guan，Ming2; Zhang，Xun2; Yang，Liu2; Wu，Sitong2; Yang，Zhichao2; Guo，Zhiyong2; Liao，Jiayan3; Zhou，Jiajia3; Lin，Fulin4,5; Ma，En4,5; Jin，Dayong2,3; Yuan，Xiaocong1

2021

10.1021/acs.nanolett.1c04909

NANO LETTERS   影响因子和分区

1530-6984

1530-6992

Conventional biomedical imaging modalities, including endoscopy, X-rays, and magnetic resonance, are invasive and insufficient in spatial and temporal resolutions for gastrointestinal (GI) tract imaging to guide prognosis and therapy. Here we report a noninvasive method based on lanthanide-doped nanocrystals with ∼1530 nm fluorescence in the near-infrared-IIb window (NIR-IIb, 1500-1700 nm). The rational design of nanocrystals have led to an absolute quantum yield (QY) up to 48.6%. Further benefiting from the minimized scattering through the NIR-IIb window, we enhanced the spatial resolution to ∼1 mm in GI tract imaging, which is ∼3 times higher compared with the near-infrared-IIa (NIR-IIa, 1000-1500 nm) method. The approach also realized a high temporal resolution of 8 frames per second; thus the moment of mice intestinal peristalsis can be captured. Furthermore, with a light-sheet imaging system, we demonstrated a three-dimensional (3D) imaging on the GI tract. Moreover, we successfully translated these advances to diagnose inflammatory bowel disease.

gastrointestinal tract inflammatory bowel disease lanthanide NIR-II imaging three-dimensional imaging

SCI ; EI

英语

NI论文

通讯

National Natural Science Foundation of China[62005179] ; China Postdoctoral Science Foundation[2020M682866] ; Major International (Regional) Joint Research Project of NSFC[51720105015] ; Shenzhen Science and Technology Program["KQTD20170810110913065",20200925174735005] ; Guangdong Major Project of Basic Research[2020B0301030009]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000812764300001

AMER CHEMICAL SOC

20221511945802

Diagnosis ; Fluorescence imaging ; Imaging systems ; Magnetic resonance ; Mammals ; Medical imaging ; Nanocrystals ; Noninvasive medical procedures ; Rare earth elements

Biomedical Engineering:461.1 ; Medicine and Pharmacology:461.6 ; Rare Earth Metals:547.2 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Imaging Techniques:746 ; Nanotechnology:761 ; Crystalline Solids:933.1

MATERIALS SCIENCE

2-s2.0-85127621296

Scopus

1.Nanophotonics Research Center,Shenzhen Key Laboratory of Micro-Scale Optical Information Technology,Institute of Microscale Optoelectronics,Shenzhen University,Shenzhen,Guangdong,518055,China
2.UTS-SUStech Joint Research Centre for Biomedical Materials and Devices,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
3.Institute for Biomedical Materials and Devices (IBMD),Faculty of Science,University of Technology Sydney,Sydney,2007,Australia
4.CAS Key Laboratory of Design and Assembly of Functional Nanostructures,Fujian Key Laboratory of Nanomaterials,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou,Fujian,350002,China
5.Xiamen Institute of Rare Earth Materials,Haixi Institute,Chinese Academy of Sciences,Xiamen,361021,China

Mi，Chao,Guan，Ming,Zhang，Xun,et al. High Spatial and Temporal Resolution NIR-IIb Gastrointestinal Imaging in Mice[J]. NANO LETTERS,2021,22(7):2793-2800.

Mi，Chao.,Guan，Ming.,Zhang，Xun.,Yang，Liu.,Wu，Sitong.,...&Yuan，Xiaocong.(2021).High Spatial and Temporal Resolution NIR-IIb Gastrointestinal Imaging in Mice.NANO LETTERS,22(7),2793-2800.

Mi，Chao,et al."High Spatial and Temporal Resolution NIR-IIb Gastrointestinal Imaging in Mice".NANO LETTERS 22.7(2021):2793-2800.