Global Exposure to Per- and Polyfluoroalkyl Substances and Associated Burden of Low Birthweight

Fan，Xiarui1; Tang，Song2,3; Wang，Ying1; Fan，Wenhong1,4; Ben，Yujie5; Naidu，Ravi6,7; Dong，Zhaomin1

2021

10.1021/acs.est.1c08669

ENVIRONMENTAL SCIENCE & TECHNOLOGY   影响因子和分区

0013-936X

1520-5851

Low birthweight (LBW) is a worldwide public health concern, while the global burden of LBW attributable to endocrine-disrupting chemicals, such as per- and polyfluoroalkyl substances (PFAS), has not yet been evaluated. Here, we established a large dataset for the biomonitoring of seven representative congeners of PFAS by examining data from 2325 publications. Global exposure to perfluorooctanesulfonic acid (PFOS) was the highest, followed by perfluorohexanesulfonic acid (PFHxS) and perfluorooctanoic acid (PFOA). Spatiotemporal exposure to PFAS varied considerably, with daily intake estimated in the range of 0.01-1.7 ng/kg/day. Moreover, decreasing trends in PFOS, PFHxS, and PFOA exposure were noted in most regions of the world over the past two decades, but such trends were not observed for other PFAS with long carbon chains, especially in East Asia. Furthermore, we estimated that human exposure to PFOA contributed to approximately 461,635 (95% confidence interval: 57,418 to 854,645) cases per year of LBW during the past two decades, predominantly from Asian regions. Although our estimation may be constrained by uncertainties from the dose-response curve and data availability, this study has unveiled that PFAS might be a contributor to global LBW prevalence during 2000-2019, supporting continuous actions to mitigate PFAS contamination.

burden disease global low birthweight meta-analysis PFAS

EI

英语

NI论文

其他

20221411883822

Endocrine disrupters

Health Care:461.7 ; Data Processing and Image Processing:723.2

ENVIRONMENT/ECOLOGY

2-s2.0-85127415446

Scopus

1.School of Space and Environment,Beihang University,Beijing,100191,China
2.China CDC Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing,100021,China
3.Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu,211166,China
4.Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,Beihang University,Beijing,100191,China
5.State Environ. Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control,School of Environmental Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
6.Global Centre for Environmental Remediation (GCER),The University of Newcastle,ATC Building,Callaghan,2308,Australia
7.CRC for Contamination Assessment and Remediation of the Environment (CRC CARE),The University of Newcastle,ATC Building,Callaghan,2308,Australia

Fan，Xiarui,Tang，Song,Wang，Ying,et al. Global Exposure to Per- and Polyfluoroalkyl Substances and Associated Burden of Low Birthweight[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2021,56:4282-4294.

Fan，Xiarui.,Tang，Song.,Wang，Ying.,Fan，Wenhong.,Ben，Yujie.,...&Dong，Zhaomin.(2021).Global Exposure to Per- and Polyfluoroalkyl Substances and Associated Burden of Low Birthweight.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56,4282-4294.

Fan，Xiarui,et al."Global Exposure to Per- and Polyfluoroalkyl Substances and Associated Burden of Low Birthweight".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56(2021):4282-4294.