Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis

Balachandran，Yekkuni L.1; Wang，Wei2; Yang，Hongyi3; Tong，Haiyang3; Wang，Lulu3; Liu，Feng2; Chen，Hongsong2; Zhong，Kai3; Liu，Ye4; Jiang，Xingyu1

2021

10.1021/acsnano.1c10618

ACS Nano   影响因子和分区

1936-0851

1936-086X

Challenges remain in precisely diagnosing the progress of liver fibrosis in a noninvasive way. We here synthesized small (4 nm) heterogeneous iron oxide/dysprosium oxide nanoparticles (IO-DyO NPs) as a contrast agent (CA) for magnetic resonance imaging (MRI) to precisely diagnose liver fibrosis in vivo at both 7.0 and 9.4 T field strength. Our IO-DyO NPs can target the liver and show an increased T2 relaxivity along with an increase of magnetic field strength. At a ultrahigh magnetic field, IO-DyO NPs can significantly improve spatial/temporal image resolution and signal-to-noise ratio of the liver and precisely distinguish the early and moderate liver fibrosis stages. Our IO-DyO NP-based MRI diagnosis can exactly match biopsy (a gold standard for liver fibrosis diagnosis in the clinic) but avoid the invasiveness of biopsy. Moreover, our IO-DyO NPs show satisfactory biosafety in vitro and in vivo. This work illustrates an advanced T2 CA used in ultrahigh-field MRI (UHFMRI) for the precise diagnosis of liver fibrosis via a noninvasive means.

iron oxide-dysprosium oxide nanoparticles liver fibrosis MRI contrast agent noninvasive detection ultrahigh-field MRI

SCI ; EI

英语

NI论文

第一 ; 通讯

National Key R&D Program of China["2018YFA0902600","2017YFA0205901"] ; National Natural Science Foundation of China[21535001,81730051,21761142006,81501790,21874033] ; Chinese Academy of Sciences["QYZDJ-SSW-SLH039","121D11KYSB20170026","XDA16020902"] ; Tencent Foundation through the XPLORER PRIZE the Leading Medical Talents Program of Health Commission of Yunnan Province[L-2018013]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000813098400001

AMER CHEMICAL SOC

20221411883884

Biopsy ; Dysprosium compounds ; Image enhancement ; Image resolution ; Iron oxides ; Magnetic fields ; Nanomagnetics ; Signal to noise ratio ; Synthesis (chemical)

Medicine and Pharmacology:461.6 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Information Theory and Signal Processing:716.1 ; Imaging Techniques:746 ; Chemical Reactions:802.2 ; Inorganic Compounds:804.2

2-s2.0-85127389418

Scopus

1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd, Nanshan District, Guangdong,518055,China
2.Peking University People's Hospital,Peking University,Hepatology Institute,Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases,Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis,Beijing,100044,China
3.High Field Magnetic Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei,230031,China
4.Institute of Medical Biology,Chinese Academy of Medical Sciences,Peking Union Medical College,Kunming,Yunnan,650000,China

Balachandran，Yekkuni L.,Wang，Wei,Yang，Hongyi,et al. Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis[J]. ACS Nano,2021,16(4):5647-5659.

Balachandran，Yekkuni L..,Wang，Wei.,Yang，Hongyi.,Tong，Haiyang.,Wang，Lulu.,...&Jiang，Xingyu.(2021).Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis.ACS Nano,16(4),5647-5659.

Balachandran，Yekkuni L.,et al."Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis".ACS Nano 16.4(2021):5647-5659.