Pinpointing Cancer Sub-Type Specific Metabolic Tasks Facilitates Identification of Anti-cancer Targets

Gao，Shuaishi1; Dai，Ziwei2; Xu，Hanyu3; Lai，Luhua1,3,4,5

2022-03-23

10.3389/fmed.2022.872024

Frontiers in Medicine   影响因子和分区

2296-858X

Metabolic reprogramming is one of the hallmarks of tumorigenesis. Understanding the metabolic changes in cancer cells may provide attractive therapeutic targets and new strategies for cancer therapy. The metabolic states are not the same in different cancer types or subtypes, even within the same sample of solid tumors. In order to understand the heterogeneity of cancer cells, we used the Pareto tasks inference method to analyze the metabolic tasks of different cancers, including breast cancer, lung cancer, digestive organ cancer, digestive tract cancer, and reproductive cancer. We found that cancer subtypes haves different propensities toward metabolic tasks, and the biological significance of these metabolic tasks also varies greatly. Normal cells treat metabolic tasks uniformly, while different cancer cells focus on different pathways. We then integrated the metabolic tasks into the multi-objective genome-scale metabolic network model, which shows higher accuracy in the in silico prediction of cell states after gene knockout than the conventional biomass maximization model. The predicted potential single drug targets could potentially turn into biomarkers or drug design targets. We further implemented the multi-objective genome-scale metabolic network model to predict synthetic lethal target pairs of the Basal and Luminal B subtypes of breast cancer. By analyzing the predicted synthetic lethal targets, we found that mitochondrial enzymes are potential targets for drug combinations. Our study quantitatively analyzes the metabolic tasks of cancer and establishes cancer type-specific metabolic models, which opens a new window for the development of specific anti-cancer drugs and provides promising treatment plans for specific cancer subtypes.

cancer metabolism metabolic network metabolic task multi-objective synthetic lethality

SCI

英语

其他

General & Internal Medicine

Medicine, General & Internal

WOS:000781500000001

FRONTIERS MEDIA SA

2-s2.0-85128164276

Scopus

1.Center for Quantitative Biology,Academy for Advanced Interdisciplinary Studies,Peking University,Beijing,China
2.Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,China
3.BNLMS,College of Chemistry and Molecular Engineering,Peking University,Beijing,China
4.Peking-Tsinghua Center for Life Sciences,Peking University,Beijing,China
5.Research Unit of Drug Design Method,Chinese Academy of Medical Sciences,Beijing,China

Gao，Shuaishi,Dai，Ziwei,Xu，Hanyu,et al. Pinpointing Cancer Sub-Type Specific Metabolic Tasks Facilitates Identification of Anti-cancer Targets[J]. Frontiers in Medicine,2022,9.

Gao，Shuaishi,Dai，Ziwei,Xu，Hanyu,&Lai，Luhua.(2022).Pinpointing Cancer Sub-Type Specific Metabolic Tasks Facilitates Identification of Anti-cancer Targets.Frontiers in Medicine,9.

Gao，Shuaishi,et al."Pinpointing Cancer Sub-Type Specific Metabolic Tasks Facilitates Identification of Anti-cancer Targets".Frontiers in Medicine 9(2022).