Bioinspired 3D Printing of Functional Materials by Harnessing Enzyme-Induced Biomineralization

Chen，Guangda1; Liang，Xiangyu1; Zhang，Pei1; Lin，Shaoting2; Cai，Chengcheng1; Yu，Ziyi3; Liu，Ji1,4,5

2022

10.1002/adfm.202113262

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

Nature builds structurally ordered and environmentally adaptive composite materials by harnessing biologically catalyzed mineralization under mild conditions. Despite recent advancements in engineering conventional materials with microorganisms through biomimetic mineralization, it remains difficult to produce mineralized composites that integrate the hierarchical structure and living attributes of their natural counterparts. Here, a kind of functional material is developed by integrating 3D printed hydrogel architectures with enzyme-induced biomineralization. It is shown that the enzyme-induced mineralization intensely transforms flexible and soft hydrogels (modulus of 125 kPa) to rigid (150 MPa) and highly mineralized hydrogel composites. Coupling with embedded 3D printing, sophisticated and mineralized free-form architectures are fabricated in the absence of sacrificial inks, which were previously unattainable through conventional manufacturing strategies. Moreover, by exploiting multi-material 3D printing to tailor the construct composition, exquisite control over the mineral distribution within the hydrogel constructs can be achieved, thus composite materials with tessellated architectures and unconventional mechanics could be obtained. The study provides a viable means to fabricate composite materials with high-fidelity architectures and tailored mechanical properties, unlocking paths to the next generation of functional materials and structures by integrating 3D printing with biomineralization.

3D printing biomineralization embedded 3D printing hydrogels tessellated structures

SCI ; EI

英语

NI论文

第一 ; 通讯

Shenzhen municipal government[Y01336223] ; SUSTech[Y01346002] ; MechERE Centers at MIT[Y01346002] ; MechERE Centers at SUSTech[Y01346002] ; Science, Technology, and Innovation Commission of Shenzhen Municipality[ZDSYS20200811143601004] ; Basic and Applied Basic Research Foundation of Guangdong Province[2020A1515110288] ; Basic Research Program of Shenzhen[JCYJ20210324105211032] ; Excellent Scientific and Technological Innovation Talents Training Program of Shenzhen[RCBS20210609103713046]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000783501200001

WILEY-V C H VERLAG GMBH

20221611973444

Biomimetic materials ; Biomimetics ; Biomineralization ; Composite materials ; Enzymes ; Functional materials ; Hydrogels ; Mineralogy

Biotechnology:461.8 ; Biology:461.9 ; Mineralogy:482 ; Printing Equipment:745.1.1 ; Biochemistry:801.2 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Materials Science:951

MATERIALS SCIENCE

2-s2.0-85128200061

Scopus

1.Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Department of Mechanical Engineering,Massachusetts Institute of Technology,Cambridge,02139,United States
3.State Key Laboratory of Materials-Oriented Chemical Engineering,College of Chemical Engineering,Nanjing Tech University,Nanjing,211816,China
4.Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems,Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,518055,China
5.Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities,Southern University of Science and Technology,Shenzhen,518055,China

Chen，Guangda,Liang，Xiangyu,Zhang，Pei,et al. Bioinspired 3D Printing of Functional Materials by Harnessing Enzyme-Induced Biomineralization[J]. ADVANCED FUNCTIONAL MATERIALS,2022,32.

Chen，Guangda.,Liang，Xiangyu.,Zhang，Pei.,Lin，Shaoting.,Cai，Chengcheng.,...&Liu，Ji.(2022).Bioinspired 3D Printing of Functional Materials by Harnessing Enzyme-Induced Biomineralization.ADVANCED FUNCTIONAL MATERIALS,32.

Chen，Guangda,et al."Bioinspired 3D Printing of Functional Materials by Harnessing Enzyme-Induced Biomineralization".ADVANCED FUNCTIONAL MATERIALS 32(2022).