南方科技大学知识苑(SUSTech KC): Phosphine-Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines

题名	Phosphine-Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines
作者	Zhang, Fuhao1,2 ; Dai, Xuan 1; Dai, Lei 1; Zheng, Wenrui 1; Chan, Wai-Lun 1; Tang, Xiaodong 1; Zhang, Xumu2 ; Lu, Yixin 1
通讯作者	Lu, Yixin
发表日期	2022-04-01
DOI	10.1002/anie.202203212
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 影响因子和分区
ISSN	1433-7851
EISSN	1521-3773
摘要	A phosphine-catalyzed highly enantioselective and diastereoselective (up to 98 % ee and >20 : 1 dr) (3+2) annulation between vinylcyclopropanes and N-tosylaldimines has been developed, which allows facile access to a range of highly functionalized chiral pyrrolidines. Notably, this method makes use of vinylcyclopropanes as a synthon for phosphine-mediated asymmetric annulation reaction, which will offer new opportunities for potential applications of cyclopropanes substrates in phosphine-catalyzed organic transformations.
关键词	Annulation Enantioselective Phosphine Catalysis Pyrrolidines Vinylcyclopropanes
相关链接	[来源记录]
收录类别	SCI ; EI
语种	英语
重要成果	NI论文
学校署名	其他
资助项目	Singapore National Research Foundation, Prime Minister's Office for the NRF Investigatorship Award[A-0004067-00-02] ; Ministry of Education of Singapore[A-0008481-00-00]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000783565500001
出版者	WILEY-V C H VERLAG GMBH
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：33
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/332983
专题	理学院_化学系
作者单位	1.Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore 2.Southern Univ Sci & Technol, Dept Chem, Xueyuan Rd, Shenzhen 518055, Peoples R China
第一作者单位	化学系
推荐引用方式 GB/T 7714	Zhang, Fuhao,Dai, Xuan,Dai, Lei,et al. Phosphine-Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022.
APA	Zhang, Fuhao.,Dai, Xuan.,Dai, Lei.,Zheng, Wenrui.,Chan, Wai-Lun.,...&Lu, Yixin.(2022).Phosphine-Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA	Zhang, Fuhao,et al."Phosphine-Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022).