A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding

Lu, Liangmei1; Zhou, Wen2; Chen, Zhuzuan1; Hu, Yang1; Yang, Yu1; Zhang, Guangzhao3; Yang, Zhuohong1

2022-04-01

10.3390/gels8040244

GELS   影响因子和分区

2310-2861

The increasing preference for minimally invasive surgery requires novel soft materials that are injectable, with rapid self-healing abilities, and biocompatible. Here, by utilizing the synergetic effect of hydrophobic interaction and quadruple hydrogen bonding, an injectable supramolecular hydrogel with excellent self-healing ability was synthesized. A unique ABA triblock copolymer was designed containing a central poly(ethylene oxide) block and terminal poly(methylmethacrylate) (PMMA) block, with ureido pyrimidinone (UPy) moieties randomly incorporated (termed MA-UPy-PEO-UPy-MA). The PMMA block could offer a hydrophobic microenvironment for UPy moieties in water and thus boost the corresponding quadruple hydrogen bonding interaction of Upy-Upy dimers. Owing to the synergetic effect of hydrophobicity and quadruple hydrogen bonding interaction, the obtained MA-UPy-PEO-UPy-MA hydrogel exhibited excellent self-healing properties, and injectable capability, as well as superior mechanical strength, and therefore, it holds great promise in tissue engineering applications, including in cell support and drug release.

supramolecular self-assembly self-healing injectable synergetic effect quadruple hydrogen bonding

SCI

英语

通讯

Basic and applied basic research project of Guangzhou City[202102020747] ; Medical and Health Science and Technology Project of Shantou City[210625106490734] ; Open Fund for Key Lab of Guangdong High Property and Functional Macromolecular Materials, China[20190012]

Polymer Science

Polymer Science

WOS:000785050300001

MDPI

Web of Science

1.South China Agr Univ, Coll Mat & Energy, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Peoples R China
2.Shantou Univ, Affiliated Hosp 2, Dept Neurosurg, Med Coll, 69 North Dongxia Rd, Shantou 515041, Peoples R China
3.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Guangdong Prov Key Lab Energy Mat Elect Power, Shenzhen 518055, Peoples R China

Lu, Liangmei,Zhou, Wen,Chen, Zhuzuan,et al. A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding[J]. GELS,2022,8(4).

Lu, Liangmei.,Zhou, Wen.,Chen, Zhuzuan.,Hu, Yang.,Yang, Yu.,...&Yang, Zhuohong.(2022).A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding.GELS,8(4).

Lu, Liangmei,et al."A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding".GELS 8.4(2022).