The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Mediated the Relationship Between Frailty and Arterial Stiffness in Older Adults

Jiang, Xin1,2,3; Cai, Yurun4,5; Wu, Xiaoyan1,2; Huang, Baofeng1,2,3; Chen, Yurong1; Zhong, Lilian1,2,3; Gao, Xia1,2,3; Guo, Yi2,3,6,7; Zhou, Junhong8,9,10

2022-02-01

10.1093/gerona/glac035

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES   影响因子和分区

1079-5006

1758-535X

Background Beat-to-beat blood pressure (BP) is an important cardiovascular output and regulated by neurophysiological elements over multiple temporal scales. The multiscale dynamics of beat-to-beat BP fluctuation can be characterized by "BP complexity" and has been linked to age-related adverse health outcomes. We here aimed to examine whether BP complexity mediates the association between arterial stiffness and frailty. Method This cross-sectional study was completed between January and October 2021. A total of 350 older adults completed assessments for frailty, arterial stiffness (ie, average brachial-ankle pulse wave velocity), and beat-to-beat finger BP. The complexity of beat-to-beat systolic blood pressure (SBP) and diastolic blood pressure (DBP) BP series was measured using multiscale entropy. The relationships between frailty, BP complexity, and arterial stiffness were examined using analysis of variance and linear regression models. The effects of BP complexity on the association between arterial stiffness and frailty were examined using mediation analyses. Results Compared with non-frail, prefrail, and frail groups had significantly elevated lower SBP and DBP complexity (F > 11, p < .001) and greater arterial stiffness (F = 16, p < .001). Greater arterial stiffness was associated with lower BP complexity (beta < -0.42, p < .001). Beat-to-beat SBP and DBP complexity mediated the association between arterial stiffness and frailty (indirect effects >0.28), accounting for at least 47% of its total effects on frailty (mediated proportion: SBP: 50%, DBP: 47%). Conclusion This study demonstrates the association between BP complexity and frailty in older adults, and BP complexity mediates the association between arterial stiffness and frailty, suggesting that this metric would serve as a marker to help characterize important functions in the older adults.

Arterial stiffness Beat-to-beat blood pressure Frailty Multiscale entropy

SCI ; SSCI

英语

通讯

Sustainable Development Science and Technology Project of Shenzhen Science and Technology Innovation Commission["KCXFZ20201221173411032","KCXFZ20201221173400001"] ; Shenzhen Science and Technology planning project[JCYJ20190807145209306] ; Natural Science Foundation of Guangdong Province[2021A1515010983] ; Shenzhen Key Medical Discipline Construction Fund["SZXK012","SZXK005"] ; National Institutes of Health[1K01AG075180-01]

Geriatrics & Gerontology

Geriatrics & Gerontology ; Gerontology

WOS:000784541900001

OXFORD UNIV PRESS INC

CLINICAL MEDICINE

Web of Science

1.Shenzhen Peoples Hosp, Dept Geriatr, Shenzhen, Guangdong, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
4.Univ Pittsburgh, Sch Nursing, Dept Hlth & Community Syst, Pittsburgh, PA 15261 USA
5.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
6.Shenzhen Peoples Hosp, Dept Neurol, 1017 Dongmen Rd N, Shenzhen 518020, Guangdong, Peoples R China
7.Shenzhen Bay Lab, Shenzhen, Guangdong, Peoples R China
8.Hebrew SeniorLife, Hinda & Arthur Marcus Inst Aging Res, Roslindale, MD USA
9.Beth Israel Deaconess Med Ctr, Div Gerontol, Boston, MA USA
10.Harvard Med Sch, Boston, MA 02115 USA

Jiang, Xin,Cai, Yurun,Wu, Xiaoyan,et al. The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Mediated the Relationship Between Frailty and Arterial Stiffness in Older Adults[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2022.

Jiang, Xin.,Cai, Yurun.,Wu, Xiaoyan.,Huang, Baofeng.,Chen, Yurong.,...&Zhou, Junhong.(2022).The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Mediated the Relationship Between Frailty and Arterial Stiffness in Older Adults.JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.

Jiang, Xin,et al."The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Mediated the Relationship Between Frailty and Arterial Stiffness in Older Adults".JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2022).