Glutathione-Depleting Organic Metal Adjuvants for Effective NIR-II Photothermal Immunotherapy

Chen, Yun1,2; He, Peiying1; Jana, Deblin2; Wang, Dongdong2; Wang, Menghao3,4; Yu, Peiyuan3,4; Zhu, Wei1; Zhao, Yanli2

2022-04-01

10.1002/adma.202201706

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

Although photothermal immunotherapy (PTI) is a compelling strategy for tumor therapy, the development of promising photothermal agents to overcome the insufficient immunogenicity of tumor cells and the poor immune response encountered in PTI is still challenging. Herein, commercial small-molecule-based organic metal adjuvants (OMAs) are presented, with second near-infrared photoacoustic and photothermal properties as well as the ability to perturb redox homeostasis to potentiate immunogenicity and immune responsiveness. OMAs, assembled from charge-transfer complexes and characterized by a broad substrate scope, high accessibility, and flexibly tuned optical properties, demonstrate strong phototherapeutic and adjuvant abilities via the depletion of glutathione and cysteine, and subsequently elicit systemic immunity by evoking immunogenic cell death, promoting dendritic cell maturation, and increasing T cell infiltration. Furthermore, programmed cell death protein 1 antibody can be employed to synergize with OMAs to suppress tumor immune evasion and ultimately improve the treatment outcomes. This study unlocks new paradigms to provide a versatile OMA-based scaffold for future practical applications.

cancer treatment glutathione depletion organic metal adjuvants photoacoustic imaging photothermal immunotherapy

SCI ; EI

英语

NI论文

其他

National Natural Science Foundation of China[21972047] ; Guangdong Provincial Pearl River Talents Program[2019QN01Y314] ; Program for Guangdong Introducing Innovative and Entrepreneurial Teams[2019ZT08Y318] ; Natural Science Foundation of Guangdong Province China[2021A1515010724] ; China Postdoctoral Science Foundation[2021M691063] ; Fundamental Research Funds for the Central Universities of China, Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant[A20E5c0081] ; Singapore National Research Foundation Investigatorship[NRF-NRFI2018-03]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000786417700001

WILEY-V C H VERLAG GMBH

20221712026011

Amino acids ; Cell death ; Charge transfer ; Infrared devices ; Optical properties ; Photoacoustic effect ; T-cells ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Immunology:461.9.1 ; Light/Optics:741.1 ; Acoustic Waves:751.1 ; Chemical Reactions:802.2 ; Organic Compounds:804.1

MATERIALS SCIENCE

Web of Science

1.South China Univ Technol, Sch Biol & Biol Engn, MOE Int Joint Res Lab Synthet Biol & Med, Guangzhou 510006, Peoples R China
2.Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, 21 Nanyang Link, Singapore 637371, Singapore
3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China
4.Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China

Chen, Yun,He, Peiying,Jana, Deblin,et al. Glutathione-Depleting Organic Metal Adjuvants for Effective NIR-II Photothermal Immunotherapy[J]. ADVANCED MATERIALS,2022,34.

Chen, Yun.,He, Peiying.,Jana, Deblin.,Wang, Dongdong.,Wang, Menghao.,...&Zhao, Yanli.(2022).Glutathione-Depleting Organic Metal Adjuvants for Effective NIR-II Photothermal Immunotherapy.ADVANCED MATERIALS,34.

Chen, Yun,et al."Glutathione-Depleting Organic Metal Adjuvants for Effective NIR-II Photothermal Immunotherapy".ADVANCED MATERIALS 34(2022).