南方科技大学知识苑(SUSTech KC): Effect of midazolam on delirium in critically ill patients: a propensity score analysis

题名	Effect of midazolam on delirium in critically ill patients: a propensity score analysis
作者	Shi, He-Jie 1,2,3; Yuan, Rui-Xia 1,2,3; Zhang, Jun-Zhi 1,2,3; Chen, Jia-Hui 1,2,3; Hu, An-Min 1,2,3
通讯作者	Hu, An-Min
发表日期	2022-04-01
DOI	10.1177/03000605221088695
发表期刊	JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 影响因子和分区
ISSN	0300-0605
EISSN	1473-2300
卷号	50 期号:4
摘要	Objective To observe the association between exposure to midazolam within 24 hours prior to delirium assessment and the risk of delirium. Methods We performed a systematic cohort study with two sets of cohorts to estimate the relative risks of outcomes among patients administered midazolam within 24 hours prior to delirium assessment. Propensity score matching was performed to generate a balanced 1:1 matched cohort and identify potential prognostic factors. The outcomes included the odds of delirium, mortality, length of intensive care unit stay, length of hospitalization, and odds of being discharged home. Results A total of 78,364 patients were included in this study, of whom 22,159 (28.28%) had positive records. Propensity matching successfully balanced covariates for 9348 patients (4674 per group). Compared with no administration of midazolam, midazolam administration was associated with a significantly higher risk of delirium, higher mortality, and a longer intensive care unit stay. Patients treated with midazolam were relatively less likely to be discharged home. There was no significant difference in hospitalization duration. Conclusions Midazolam may be an independent risk factor for delirium in critically ill patients.
关键词	Midazolam delirium critical care propensity score analysis cohort study risk factor
相关链接	[来源记录]
收录类别	SCI ; SSCI
语种	英语
学校署名	通讯
资助项目	Medical Science and Technology Research Fund of Guangdong Province[A2021058] ; Clinical Agent Research Fund of Guangdong Province[2022MZ12]
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS记录号	WOS:000787546800001
出版者	SAGE PUBLICATIONS LTD
ESI学科分类	CLINICAL MEDICINE
来源库	Web of Science
引用统计	被引频次[WOS]：8
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/333455
专题	南方科技大学第一附属医院
作者单位	1.Shenzhen Peoples Hosp, Dept Anesthesiol, 1017 Dongmen St, Shenzhen 518020, Guangdong, Peoples R China 2.Jinan Univ, Clin Med Coll 2, Shenzhen, Peoples R China 3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Shi, He-Jie,Yuan, Rui-Xia,Zhang, Jun-Zhi,et al. Effect of midazolam on delirium in critically ill patients: a propensity score analysis[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2022,50(4).
APA	Shi, He-Jie,Yuan, Rui-Xia,Zhang, Jun-Zhi,Chen, Jia-Hui,&Hu, An-Min.(2022).Effect of midazolam on delirium in critically ill patients: a propensity score analysis.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,50(4).
MLA	Shi, He-Jie,et al."Effect of midazolam on delirium in critically ill patients: a propensity score analysis".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 50.4(2022).