南方科技大学知识苑(SUSTech KC): Increased resistance of SARS-CoV-2 Lambda variant to antibody neutralization

题名	Increased resistance of SARS-CoV-2 Lambda variant to antibody neutralization
作者	Guo，Huimin 1; Fan，Qing1 ; Song，Shuo1 ; Shen，Senlin1 ; Zhou，Bing1 ; Wang，Haiyan 1; Cheng，Lin 1; Ge，Xiangyang 1; Ju，Bin 1,2; Zhang，Zheng 1,2,3
通讯作者	Ju，Bin
发表日期	2022-06-01
DOI	10.1016/j.jcv.2022.105162
发表期刊	JOURNAL OF CLINICAL VIROLOGY 影响因子和分区
ISSN	1386-6532
EISSN	1873-5967
卷号	150
摘要	A recently identified SARS-CoV-2 variant, Lambda, has spread to many countries around the world. Here, we measured and evaluated the reduced sensitivity of Lambda variant to the neutralization by plasma polyclonal antibodies elicited by the natural SARS-CoV-2 infection and inactivated vaccine. The combination of two substitutions appearing in the RBD of spike protein (L452Q and F490S) resulted in noticeably reduced neutralization against Lambda variant. F490S contributed more than L452Q in affecting the neutralization. In addition, the neutralization test with 12 published nAbs binding to RBD of SARS-CoV-2 with defined structures suggested that Lambda variant resisted the neutralization by some antibodies from Class 2 and Class 3. Overall, these results suggest that pre-existing antibody neutralization established by natural infection from non-Lambda variants or immunization could be significantly decreased, re-emphasizing the importance of ongoing viral mutation monitoring.
关键词	SARS-CoV-2 Lambda variant Convalescent plasma Inactivated vaccine Monoclonal antibody Neutralization
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Science Fund for Distinguished Young Scholars[82025022] ; National Natural Science Foundation of China["82002140","82171752","82101861"] ; Guangdong Basic and Applied Basic Research Foundation["2021B1515020034","2019A1515011197","2021A1515011009","2020A1515110656"] ; Shenzhen Science and Technology Program["RCYX20200714114700046","JSGG20200207155251653","JSGG20200807171401008","KQTD20200909113758004","JCYJ20190809115617365"]
WOS研究方向	Virology
WOS类目	Virology
WOS记录号	WOS:000830916500003
出版者	ELSEVIER
ESI学科分类	MICROBIOLOGY
Scopus记录号	2-s2.0-85128672868
来源库	Web of Science
引用统计	被引频次[WOS]：8
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/333589
专题	南方科技大学医学院南方科技大学第二附属医院
作者单位	1.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital; The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong Province,518112,China 2.Guangdong Key laboratory for anti-infection Drug Quality Evaluation,Shenzhen,Guangdong Province,518112,China 3.Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science,Shenzhen,Guangdong Province,518112,China
第一作者单位	南方科技大学医学院; 南方科技大学第二附属医院
通讯作者单位	南方科技大学医学院; 南方科技大学第二附属医院
第一作者的第一单位	南方科技大学医学院; 南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Guo，Huimin,Fan，Qing,Song，Shuo,et al. Increased resistance of SARS-CoV-2 Lambda variant to antibody neutralization[J]. JOURNAL OF CLINICAL VIROLOGY,2022,150.
APA	Guo，Huimin.,Fan，Qing.,Song，Shuo.,Shen，Senlin.,Zhou，Bing.,...&Zhang，Zheng.(2022).Increased resistance of SARS-CoV-2 Lambda variant to antibody neutralization.JOURNAL OF CLINICAL VIROLOGY,150.
MLA	Guo，Huimin,et al."Increased resistance of SARS-CoV-2 Lambda variant to antibody neutralization".JOURNAL OF CLINICAL VIROLOGY 150(2022).