Visible-Light-Induced α,γ-C(sp3)-H Difunctionalization of Piperidines

Wang，Biao1; Zhou，Min Jie2; Zhou，Qi Lin1,3

2022-04-22

10.1021/acs.orglett.2c00831

ORGANIC LETTERS   影响因子和分区

1523-7060

1523-7052

Herein, we describe a novel protocol for visible-light-induced α,γ-C(sp3)-H difunctionalization of piperidines. This redox-neutral, atom-economical protocol, which exhibits a broad substrate scope and good functional group compatibility, constitutes a concise, practical method for constructing piperidine-containing bridged-ring molecules. Preliminary mechanistic studies indicated that highly regioselective activation of the inert γ-C(sp3)-H bond of piperidines was achieved through a 1,5-hydrogen atom transfer reaction of a nitrogen radical generated in situ.

SCI

英语

NI论文

其他

National Natural Science Foundation of China[21790332,91956000,22188101] ; "111" project[B06005]

Chemistry

Chemistry, Organic

WOS:000794996900022

AMER CHEMICAL SOC

CHEMISTRY

2-s2.0-85128795011

Scopus

1.State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,300071,China
2.Shenzhen Grubbs Institute and Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China
3.Haihe Laboratory of Sustainable Chemical Transformations,300192,China

Wang，Biao,Zhou，Min Jie,Zhou，Qi Lin. Visible-Light-Induced α,γ-C(sp3)-H Difunctionalization of Piperidines[J]. ORGANIC LETTERS,2022,24(15):2894-2898.

Wang，Biao,Zhou，Min Jie,&Zhou，Qi Lin.(2022).Visible-Light-Induced α,γ-C(sp3)-H Difunctionalization of Piperidines.ORGANIC LETTERS,24(15),2894-2898.

Wang，Biao,et al."Visible-Light-Induced α,γ-C(sp3)-H Difunctionalization of Piperidines".ORGANIC LETTERS 24.15(2022):2894-2898.