Studies Progression on the Function of Autophagy in Viral Infection

Liang，Weizheng1; Liu，Huimin2; He，Junli3; Ai，Lisha4; Meng，Qingxue5; Zhang，Weiwen6; Yu，Chengwei7,8; Wang，Hao5,6; Liu，Hui9

2021-12-16

10.3389/fcell.2021.772965

Frontiers in Cell and Developmental Biology   影响因子和分区

2296-634X

Autophagy is a conservative lysosomal catabolic pathway commonly seen in eukaryotic cells. It breaks down proteins and organelles by forming a two-layer membrane structure of autophagosomes and circulating substances and maintaining homeostasis. Autophagy can play a dual role in viral infection and serve either as a pro-viral factor or an antiviral defense element dependent on the virus replication cycle. Recent studies have suggested the complicated and multidirectional role of autophagy in the process of virus infection. On the one hand, autophagy can orchestrate immunity to curtail infection. On the other hand, some viruses have evolved strategies to evade autophagy degradation, facilitating their replication. In this review, we summarize recent progress of the interaction between autophagy and viral infection. Furthermore, we highlight the link between autophagy and SARS-CoV-2, which is expected to guide the development of effective antiviral treatments against infectious diseases.

autophagy coronavirus infection SARS-CoV-2 virus

SCI

英语

通讯

WOS:000741547000001

2-s2.0-85122106320

Scopus

1.Harbin Institute of Technology,Harbin,China
2.Department of Infectious Diseases,Southwest Hospital,Third Military Medical University (Army Medical University,Chongqing,China
3.Department of Pediatrics,Shenzhen University General Hospital,Shenzhen,China
4.Department of Teaching and Research,Shenzhen University General Hospital,Shenzhen,China
5.Department of Science,Southern University of Science and Technology,Shenzhen,China
6.Department of Gynaecology and Obstetrics,Shenzhen University General Hospital,Shenzhen,China
7.School of Future Technology,University of Chinese Academy of Sciences,Beijing,China
8.CAS Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing,China
9.Department of Hepatobiliary Surgery,Shenzhen University General Hospital,Shenzhen,China

Liang，Weizheng,Liu，Huimin,He，Junli,et al. Studies Progression on the Function of Autophagy in Viral Infection[J]. Frontiers in Cell and Developmental Biology,2021,9.

Liang，Weizheng.,Liu，Huimin.,He，Junli.,Ai，Lisha.,Meng，Qingxue.,...&Liu，Hui.(2021).Studies Progression on the Function of Autophagy in Viral Infection.Frontiers in Cell and Developmental Biology,9.

Liang，Weizheng,et al."Studies Progression on the Function of Autophagy in Viral Infection".Frontiers in Cell and Developmental Biology 9(2021).