Association between cine CMR-based radiomics signature and microvascular obstruction in patients with ST-segment elevation myocardial infarction

Peng, Yongjia1; Wu, Kongyang2; Wang, Yi Xiang J.3; Gong, Jingshan4

2022-02-01

10.21037/jtd-21-1706

Journal of Thoracic Disease   影响因子和分区

2072-1439

2077-6624

Background: In the process of percutaneous coronary intervention (PCI), patients with ST-segment elevation myocardial infarction (STEMI) may receive large doses of the iodine contrast agent. Some adverse events may be aroused if the patients receive the gadolinium agents. We investigate the association between cine cardiac magnetic resonance (CMR)-based radiomics signature and microvascular obstruction (MVO) in patients with STEMI. Methods: A total of 116 STEMI patients who received continuous CMR within 6 days after PCI were retrospectively included in this study. According to the late gadolinium enhancement (LGE) of CMR, the myocardial infarction (MI) was divided into with and without MVO. Radiomic features were extracted from cine CMR images and the least absolute shrinkage and selectionator operator (LASSO) algorithm was used for features selection and radiomic signatures construction. Binary logistic regression was used to assess association between radiomic signatures and MVO with adjusted for baseline clinical characteristics. Results: Of 116 patients with STEMI, MI with MVO was found in 50 patients and MI without MVO was found in 66 patients. LASSO regression selected five radiomics features for radiomics signature construction. Logistic regression revealed that radiomics score, high sensitivity C-reactive protein (hs-CRP) and creatine phosphokinases (CPK) were independent risk factors for MVO with odds ratio (OR) of 4.41 (95% CI: 2.26- 9.93), 1.018 (95% CI: 1.006-1.034) and 1.0007 (95% CI: 1.0004-1.0012), respectively. Area under curve (AUC) of receiver operating characteristic (ROC) of radiomics score to predict MVO was 0.75 (95% CI: 0.68-0.85). Conclusions: Cine CMR-based radiomics signature was an independent predictive factor of MVO in patients with STEMI, which showed the potential of this contrast free radiomics signature to be an imaging biomarker for MVO.

Myocardial infarction microvascular obstruction (MVO) cine cardiac magnetic resonance radiomics

SCI

英语

通讯

Shenzhen Science and Technology Project[GJHZ20180928172002087]

Respiratory System

Respiratory System

WOS:000787538900001

AME PUBL CO

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Shenzhen, Peoples R China
2.Jinan Univ, Coll Elect & Informat Engn, Guangzhou, Peoples R China
3.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Diagnost Radiol & Organ Imaging, Hong Kong, Peoples R China
4.Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ, Clin Coll 2,Shenzhen Peoples Hosp,Dept Radiol, Floor 1,Bldg 4,Dongbeilu 1017, Shenzhen 518020, Peoples R China

Peng, Yongjia,Wu, Kongyang,Wang, Yi Xiang J.,et al. Association between cine CMR-based radiomics signature and microvascular obstruction in patients with ST-segment elevation myocardial infarction[J]. Journal of Thoracic Disease,2022.

Peng, Yongjia,Wu, Kongyang,Wang, Yi Xiang J.,&Gong, Jingshan.(2022).Association between cine CMR-based radiomics signature and microvascular obstruction in patients with ST-segment elevation myocardial infarction.Journal of Thoracic Disease.

Peng, Yongjia,et al."Association between cine CMR-based radiomics signature and microvascular obstruction in patients with ST-segment elevation myocardial infarction".Journal of Thoracic Disease (2022).