南方科技大学知识苑(SUSTech KC): Switchable bifunctional molecular recognition in water using a pH-responsive Endo-functionalized cavity

题名	Switchable bifunctional molecular recognition in water using a pH-responsive Endo-functionalized cavity
作者	Wang，Xiaoping; Quan，Mao; Yao，Huan; Pang，Xin Yu; Ke，Hua; Jiang，Wei
通讯作者	Jiang，Wei
发表日期	2022-12-01
DOI	10.1038/s41467-022-30012-4
发表期刊	Nature Communications 影响因子和分区
EISSN	2041-1723
卷号	13 期号:1
摘要	The construction of water-soluble synthetic hosts with a stimuli-responsive endo-functionalized cavity is challenging. These hosts feature a switchable cavity and may bring new properties to the fields of self-assembly, molecular machines, and biomedical sciences. Herein, we report a pair of water-soluble naphthotubes with a pH-responsive endo-functionalized cavity. The inward-directing secondary amine group of the hosts can be protonated and deprotonated. Thus, the hosts have different cavity features at the two states and show drastically different binding preference and selectivity in water. We reveal that the binding difference of the two host states is originated from the differences in charge repulsion, hydrogen bonding and the hydrophobic effects. Moreover, the guest binding can be easily switched in a ternary mixture with two guest molecules by adjusting the pH value of the solution. These pH-responsive hosts may be used for the construction of smart self-assembly systems and water-soluble molecular machines.
相关链接	[Scopus记录]
语种	英语
重要成果	NI论文
学校署名	第一 ; 通讯
资助项目	National Outstanding Youth Science Fund Project of National Natural Science Foundation of China[22125105];
Scopus记录号	2-s2.0-85128930932
来源库	Scopus
引用统计	被引频次[WOS]：17
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/333979
专题	理学院_化学系深圳格拉布斯研究院
作者单位	Shenzhen Grubbs Institute,Guangdong Provincial Key Laboratory of Catalysis,and Department of Chemistry,Southern University of Science and Technology,Shenzhen,Xueyuan Blvd 1088,518055,China
第一作者单位	化学系; 深圳格拉布斯研究院
通讯作者单位	化学系; 深圳格拉布斯研究院
第一作者的第一单位	化学系; 深圳格拉布斯研究院
推荐引用方式 GB/T 7714	Wang，Xiaoping,Quan，Mao,Yao，Huan,et al. Switchable bifunctional molecular recognition in water using a pH-responsive Endo-functionalized cavity[J]. Nature Communications,2022,13(1).
APA	Wang，Xiaoping,Quan，Mao,Yao，Huan,Pang，Xin Yu,Ke，Hua,&Jiang，Wei.(2022).Switchable bifunctional molecular recognition in water using a pH-responsive Endo-functionalized cavity.Nature Communications,13(1).
MLA	Wang，Xiaoping,et al."Switchable bifunctional molecular recognition in water using a pH-responsive Endo-functionalized cavity".Nature Communications 13.1(2022).