南方科技大学知识苑(SUSTech KC): 12-Month Post-Discharge Liver Function Test Abnormalities Among Patients With COVID-19: A Single-Center Prospective Cohort Study

题名	12-Month Post-Discharge Liver Function Test Abnormalities Among Patients With COVID-19: A Single-Center Prospective Cohort Study
作者	Liao，Xuejiao 1; Li，Dapeng1 ; Ma，Zhenghua 1; Zhang，Lina 1; Zheng，Baoqi 1; Li，Zhiyan 1; Li，Guobao 1; Liu，Lei1,2 ; Zhang，Zheng 1,2,3
通讯作者	Li，Guobao; Liu，Lei; Zhang，Zheng
发表日期	2022-04-14
DOI	10.3389/fcimb.2022.864933
发表期刊	Frontiers in Cellular and Infection Microbiology 影响因子和分区
ISSN	2235-2988
EISSN	2235-2988
卷号	12
摘要	Objective: The longitudinal effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the liver are unknown. This study aimed to characterize dynamic changes in liver function test abnormalities in patients with COVID-19 at the acute phase and recovery phase. Methods: A prospective cohort study involved patients with COVID-19 who were admitted to Shenzhen Third People’s Hospital between January 11, 2020, and April 27, 2020. Patients underwent liver function tests at hospitalization and at the outpatient visit at the 1-month, 3-month, 6-month, and 12-month follow-ups. Results: Among 461 patients, 28.4% of patients had any kind of liver function tests abnormality at admission, manifested as elevated ALT (13.0%), AST (17.6%), and GGT (15.8%) levels. The trajectory analysis indicated a marked improvement in liver function after discharge, with any kind of liver function test abnormalities of 25.1% at 1 month, 13.2% at 3 months, 16.7% at 6 months, and 13.2% at 12 months after discharge. Persistent liver function abnormalities were observed in patients with pre-existing conditions during follow-up. A significantly higher prevalence of ultrasound determined fatty liver disease was found in those patients with more frequent LFT abnormalities at follow-up. Conclusion: In this study of patients with COVID-19, liver damage in COVID-19 was usually temporary and could return to normal at the end of the 12-month follow-up.
关键词	alanine aminotransferase (ALT) albumin aspartate aminotransferase (AST) COVID-19 gamma-glutamyltransferase (GGT) SARS-CoV-2
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
WOS研究方向	Immunology ; Microbiology
WOS类目	Immunology ; Microbiology
WOS记录号	WOS:000795457300001
出版者	FRONTIERS MEDIA SA
Scopus记录号	2-s2.0-85128978099
来源库	Scopus
引用统计	被引频次[WOS]：14
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/333985
专题	南方科技大学医学院南方科技大学第二附属医院
作者单位	1.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People’s Hospital,The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,China 2.Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science,Shenzhen,China 3.Guangdong Key Laboratory for Anti-Infection Drug Quality Evaluation,Shenzhen,China
第一作者单位	南方科技大学医学院; 南方科技大学第二附属医院
通讯作者单位	南方科技大学医学院; 南方科技大学第二附属医院
第一作者的第一单位	南方科技大学医学院; 南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Liao，Xuejiao,Li，Dapeng,Ma，Zhenghua,et al. 12-Month Post-Discharge Liver Function Test Abnormalities Among Patients With COVID-19: A Single-Center Prospective Cohort Study[J]. Frontiers in Cellular and Infection Microbiology,2022,12.
APA	Liao，Xuejiao.,Li，Dapeng.,Ma，Zhenghua.,Zhang，Lina.,Zheng，Baoqi.,...&Zhang，Zheng.(2022).12-Month Post-Discharge Liver Function Test Abnormalities Among Patients With COVID-19: A Single-Center Prospective Cohort Study.Frontiers in Cellular and Infection Microbiology,12.
MLA	Liao，Xuejiao,et al."12-Month Post-Discharge Liver Function Test Abnormalities Among Patients With COVID-19: A Single-Center Prospective Cohort Study".Frontiers in Cellular and Infection Microbiology 12(2022).