南方科技大学知识苑(SUSTech KC): A fourth dose of Omicron RBD vaccine enhances broad neutralization against SARS-CoV-2 variants including BA.1 and BA.2 in vaccinated mice

题名	A fourth dose of Omicron RBD vaccine enhances broad neutralization against SARS-CoV-2 variants including BA.1 and BA.2 in vaccinated mice
作者	Zhou, Bing1,2 ; Song, Shuo1,2 ; Guo, Huimin 1,2; Zhou, Xinrong 1,2; Fan, Qing1,2 ; Liu, Weilong 1,2; Cheng, Lin 1,2; Ge, Xiangyang 1,2; Ju, Bin 1,2,3; Zhang, Zheng 1,2,3,4
通讯作者	Ju, Bin; Zhang, Zheng
发表日期	2022-05-01
DOI	10.1002/jmv.27811
发表期刊	JOURNAL OF MEDICAL VIROLOGY 影响因子和分区
ISSN	0146-6615
EISSN	1096-9071
卷号	94 期号:8
摘要	The SARS-CoV-2 vaccines have been widely used to build an immunologic barrier in the population against the COVID-19 pandemic. However, a newly emerging Omicron variant, including BA.1, BA.1.1, BA.2, and BA.3 sublineages, largely escaped the neutralization of existing neutralizing antibodies (nAbs), even those elicited by three doses of vaccines. Here, we used the Omicron BA.1 RBD as a fourth dose of vaccine to induce potent Omicron-specific nAbs and evaluated the broadly neutralizing activities against SARS-CoV-2 variants. The BA.1-based vaccine was indeed prone to induce a strain-specific antibody response substantially cross-reactive with BA.2 sublineage, and yet triggered broad neutralization against SARS-CoV-2 variants when it was used in the sequential immunization with WT and other variant vaccines. These results demonstrated that the booster of Omicron RBD vaccine could be a rational strategy to enhance the broadly nAb response.
关键词	neutralization Omicron variant RBD vaccine SARS-CoV-2 sequential immunization
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Science Fund for Distinguished Young Scholars[82025022] ; National Natural Science Foundation of China[92169204,82002140,82171752,82101861] ; National Key Plan for Scientific Research and Development of China[2021YFC0864500] ; Guangdong Basic and Applied Basic Research Foundation["2021B1515020034","2021A1515011009","2020A1515110656","2019A1515011197"] ; Shenzhen Science and Technology Program[RCYX20200714114700046] ; Science and Technology Innovation Committee of Shenzhen Municipality["JSGG20200207155251653","JSGG20200807171401008","JSGG202 10901145200002","KQTD20200909113758004"] ; Shenzhen Natural Science Foundation["JCYJ20210324115611032","JCYJ2021 0324131606018","JCYJ20190809115617365"]
WOS研究方向	Virology
WOS类目	Virology
WOS记录号	WOS:000791484300001
出版者	WILEY
ESI学科分类	MICROBIOLOGY
来源库	Web of Science
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/334335
专题	南方科技大学第二附属医院南方科技大学医学院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Inst Hepatol, Natl Clin Res Ctr Infect Dis, Shenzhen Peoples Hosp 3, Shenzhen 518112, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 2, Sch Med, Shenzhen 518112, Guangdong, Peoples R China 3.Guangdong Key Lab Antiinfect Drug Qual Evaluat, Shenzhen, Guangdong, Peoples R China 4.Chinese Acad Med Sci, Shenzhen Res Ctr Communicable Dis Diag & Treatmen, Shenzhen, Guangdong, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院; 南方科技大学医学院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院; 南方科技大学医学院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Zhou, Bing,Song, Shuo,Guo, Huimin,et al. A fourth dose of Omicron RBD vaccine enhances broad neutralization against SARS-CoV-2 variants including BA.1 and BA.2 in vaccinated mice[J]. JOURNAL OF MEDICAL VIROLOGY,2022,94(8).
APA	Zhou, Bing.,Song, Shuo.,Guo, Huimin.,Zhou, Xinrong.,Fan, Qing.,...&Zhang, Zheng.(2022).A fourth dose of Omicron RBD vaccine enhances broad neutralization against SARS-CoV-2 variants including BA.1 and BA.2 in vaccinated mice.JOURNAL OF MEDICAL VIROLOGY,94(8).
MLA	Zhou, Bing,et al."A fourth dose of Omicron RBD vaccine enhances broad neutralization against SARS-CoV-2 variants including BA.1 and BA.2 in vaccinated mice".JOURNAL OF MEDICAL VIROLOGY 94.8(2022).