Surface Modification of Poly(ether ether ketone) by Simple Chemical Grafting of Strontium Chondroitin Sulfate to Improve its Anti-Inflammation, Angiogenesis, Osteogenic Properties

Zheng, Zhe1; Hu, Liqiu1; Ge, Yongmei1,2; Qi, Jianchao1,3,4; Sun, Qili1; Li, Zhenjian1; Lin, Lijun3; Tang, Bin1,5,6

2022-05-01

10.1002/adhm.202200398

Advanced Healthcare Materials   影响因子和分区

2192-2640

2192-2659

Besides inducing osteogenic differentiation, the surface modification of poly(ether ether ketone) (PEEK) is highly expected to improve its angiogenic activity and reduce the inflammatory response in the surrounding tissue. Herein, strontium chondroitin sulfate is first attempted to be introduced into the surface of sulfonated PEEK (SPEEK-CS@Sr) based on the Schiff base reaction between PEEK and ethylenediamine (EDA) and the amidation reaction between EDA and chondroitin sulfate (CS). The surface characteristics of SPEEK-CS@Sr implant are systematically investigated, and its biological properties in vitro and in vivo are also evaluated. The results show that the surface of SPEEK-CS@Sr implant exhibits a 3D microporous structure and good hydrophilicity, and can steadily release Sr ions. Importantly, the SPEEK-CS@Sr not only displays excellent biocompatibility, but also can remarkably promote cell adhesion and spread, improve osteogenic activity and angiogenic activity, and reduce the inflammatory response compared to the original PEEK. Therefore, this study presents the surface modification of PEEK material by simple chemical grafting of strontium chondroitin sulfate to improve its angiogenesis, anti-inflammation, and osteogenic properties, and the as-fabricated SPEEK-CS@Sr has the potential to serve as a promising orthopedic implant in bone tissue engineering.

angiogenesis anti-inflammation chondroitin sulfate osteogenic fixation poly(ether ketone) (PEEK) strontium

SCI ; EI

英语

第一 ; 通讯

National Key Research and Development Program of China[2019YFA0906004] ; National Foundation of Science and Technology[11872200] ; Guangdong Foundation of Science and Technology[2017B030301018] ; Shenzhen Science and Technology Innovation Committee[JSGG20200225151916021]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:000791461400001

WILEY

20221912072473

Biocompatibility ; Chemical modification ; Ethers ; Pathology ; Strontium compounds ; Sulfur compounds ; Tissue ; Tissue engineering

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biology:461.9 ; Immunology:461.9.1 ; Organic Compounds:804.1

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen, Guangdong, Peoples R China
2.Harbin Inst Technol, Harbin, Heilongjiang, Peoples R China
3.Southern Med Univ, Zhujiang Hosp, Dept Joint & Orthoped, Guangzhou, Guangdong, Peoples R China
4.Fujian Med Univ, Fujian Prov Hosp, Shengli Clin Med Coll, Dept Emergency Surg, Fuzhou, Peoples R China
5.Guangdong Prov Key Lab Cell Microenvironm & Dis R, Shenzhen, Guangdong, Peoples R China
6.Shenzhen Key Lab Cell Microenvironm, Shenzhen, Guangdong, Peoples R China

Zheng, Zhe,Hu, Liqiu,Ge, Yongmei,et al. Surface Modification of Poly(ether ether ketone) by Simple Chemical Grafting of Strontium Chondroitin Sulfate to Improve its Anti-Inflammation, Angiogenesis, Osteogenic Properties[J]. Advanced Healthcare Materials,2022,11.

Zheng, Zhe.,Hu, Liqiu.,Ge, Yongmei.,Qi, Jianchao.,Sun, Qili.,...&Tang, Bin.(2022).Surface Modification of Poly(ether ether ketone) by Simple Chemical Grafting of Strontium Chondroitin Sulfate to Improve its Anti-Inflammation, Angiogenesis, Osteogenic Properties.Advanced Healthcare Materials,11.

Zheng, Zhe,et al."Surface Modification of Poly(ether ether ketone) by Simple Chemical Grafting of Strontium Chondroitin Sulfate to Improve its Anti-Inflammation, Angiogenesis, Osteogenic Properties".Advanced Healthcare Materials 11(2022).