Circular Dichroism Based Chirality Sensing with Supramolecular Host-Guest Chemistry

Quan, Mao1,2; Pang, Xin-Yu1,2; Jiang, Wei1,2

2022-05-01

10.1002/anie.202201258

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   影响因子和分区

1433-7851

1521-3773

Optical methods are promising to address the ever-increasing demands for chirality analysis in drug discovery and related fields because they are amenable to high-throughput screening. Circular dichroism-based chiroptical sensing using host-guest chemistry is especially appealing due to the fast equilibrium kinetics, wide substrate scope, and potential for sustainable development. In this Minireview, we give an overview on this emerging field. General aspects of molecular recognition and chirality transfer are analyzed. Chirality sensors are discussed by dividing them into three classes according to their structural features. Applications of these chirality sensors for chirality analysis of the products of asymmetric reactions and for the real-time monitoring of reaction kinetics are demonstrated with selected examples. Moreover, challenges and research directions in this field are also highlighted.

Chirality Analysis Chiroptical Sensing Circular Dichroism Enantioselectivity Determination Molecular Recognition

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[22101125] ; Shenzhen Science and Technology Innovation Committee[JCYJ20180504165810828] ; Guangdong High-Level Personnel of Special Support Program[2019TX05C157] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]

Chemistry

Chemistry, Multidisciplinary

WOS:000790023400001

WILEY-V C H VERLAG GMBH

20221912070802

Chemical analysis ; Chirality ; Molecular recognition ; Reaction kinetics ; Stereochemistry

Light/Optics:741.1 ; Chemistry:801 ; Chemical Reactions:802.2 ; Atomic and Molecular Physics:931.3

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol SUSTech, Guangdong Prov Key Lab Catalysis, Shenzhen Grubbs Inst, Xueyuan Blvd 1088, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol SUSTech, Dept Chem, Xueyuan Blvd 1088, Shenzhen 518055, Peoples R China

Quan, Mao,Pang, Xin-Yu,Jiang, Wei. Circular Dichroism Based Chirality Sensing with Supramolecular Host-Guest Chemistry[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022,61.

Quan, Mao,Pang, Xin-Yu,&Jiang, Wei.(2022).Circular Dichroism Based Chirality Sensing with Supramolecular Host-Guest Chemistry.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,61.

Quan, Mao,et al."Circular Dichroism Based Chirality Sensing with Supramolecular Host-Guest Chemistry".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 61(2022).