Freezing of Gait in Multiple System Atrophy

Yang, Huaguang1; Liu, Weiyin Vivian2; Wang, Shanshan3; Yang, Wenbin1; Liu, Changsheng1; Wen, Zhi1; Hu, Lanhua1; Guo, Jinxia2; Fan, Guoguang3; Luo, Xiaoguang4; Zha, Yunfei1

2022-04-08

10.3389/fnagi.2022.833287

Frontiers in Aging Neuroscience   影响因子和分区

1663-4365

Background and PurposeFreezing of gait (FOG) is a common gait disturbance phenomenon in multiple system atrophy (MSA) patients. The current investigation assessed the incidence FOG in a cross-sectional clinical study, and clinical correlations associated with it. MethodsNinety-nine MSA patients from three hospitals in China were consecutively enrolled in the study. Eight patients were subsequently excluded from the analysis due to incomplete information. The prevalence of FOG symptoms in the MSA cohort was determined, and clinical manifestations in MSA patients with and without FOG were assessed. ResultsOf 91 MSA patients, 60 (65.93%) exhibited FOG. The incidence of FOG increased with disease duration and motor severity and was correlated with modified Hoehn and Yahr (H-Y) stages [odds ratio (OR), 0.54; 95% confidence interval (CI), 0.33-3.92], longer disease duration (OR, 0.54, 95% CI, 0.37-0.78), higher Unified Multiple System Atrophy Rating Scale (UMSARS) score (OR, 0.96, 95% CI, 0.93-0.99), MSA-cerebellum subtype (OR, 2.99, 95% CI, 1.22-7.33), levodopa-equivalent dose (LDED) (OR, 0.998, 95% CI, 0.997-1.00), and higher Scale for the Assessment and Rating of Ataxia (SARA) score (OR, 0.80, 95% CI, 0.72-0.89) (logistic regression). Motor dysfunction was significantly positively associated with lower quality of life scores (p < 0.01). ConclusionFOG is a common symptom in MSA patients and it is correlated with poor quality of life, disease progression and severity, levodopa-equivalent dose, and cerebellum impairment.

multiple system atrophy freezing of gait prevalence risk factors epidemiological investigation

SCI

英语

通讯

Geriatrics & Gerontology ; Neurosciences & Neurology

Geriatrics & Gerontology ; Neurosciences

WOS:000791347000001

FRONTIERS MEDIA SA

Web of Science

1.Renmin Hosp Wuhan Univ, Dept Radiol, Wuhan, Peoples R China
2.GE Healthcare, MR Res, Beijing, Peoples R China
3.China Med Univ, Affiliated Hosp 1, Dept Radiol, Shenyang, Peoples R China
4.Jinan Univ, Clin Med Coll 2,South Univ Sci & Technol, Shenzhen Peoples Hosp,Affiliated Hosp 1, Dept Neurol, Shenzhen, Peoples R China

Yang, Huaguang,Liu, Weiyin Vivian,Wang, Shanshan,et al. Freezing of Gait in Multiple System Atrophy[J]. Frontiers in Aging Neuroscience,2022,14.

Yang, Huaguang.,Liu, Weiyin Vivian.,Wang, Shanshan.,Yang, Wenbin.,Liu, Changsheng.,...&Zha, Yunfei.(2022).Freezing of Gait in Multiple System Atrophy.Frontiers in Aging Neuroscience,14.

Yang, Huaguang,et al."Freezing of Gait in Multiple System Atrophy".Frontiers in Aging Neuroscience 14(2022).