Rational design and synthesis of novel NIR photosensitizers and application in antimicrobial photodynamic inactivation

Liu，Chuangjun1; Xiang，Jingjing2; Li，Jing2; Xiang，Chunbai2; Li，Huacheng3; Wei，Fangfang3; Zhao，Ziqi1; Li，Rongqiang1; Wong，Keith Man Chung3; Gong，Ping2

2022-09-05

10.1016/j.molstruc.2022.133138

JOURNAL OF MOLECULAR STRUCTURE   影响因子和分区

0022-2860

1872-8014

Herein we use our previously developed strategy for the synthesis of NIR photosensitizers based on Malachite Green (MG) skeleton. Firstly, we installed bipyridine group into MG to form bpy-MG, as bidentate chelating ligand, which was then bonded with [Ir(ppy)(2)Cl](2) (ppy = 2-phenylpyridine) and [Ir(dqpx)(2)Cl](2) (dqpx = 2,3-diphenylquinoxaline) through the N atoms of bipyridine to produce Ir-MG-ppy and Ir-MG-dqpx, respectively. The photosensitizers display NIR absorption with weak fluorescence and singlet oxygen generation ability because of the free rotation of the indoline moieties. Upon binding with deoxyribonucleic acid sodium salt from salmon testes, the fluorescence and singlet oxygen generation ability were greatly boosted due to the restriction of free rotation. The as-prepared photosensitizers demonstrate potential application in light-induced killing Staphylococcus aureus both in vitro and in vivo. (C) 2022 Elsevier B.V. All rights reserved.

NIR Photosensitizer Malachite green Iridium Antibacterial

SCI ; EI

英语

其他

Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20210324104609025] ; National Key Research and Development Program of China[2021YFA0910000] ; Shenzhen Science and Technology Program[JCYJ20210324115804013] ; Shenzhen-Macao Technology Plan[SGDX2020110309280301] ; National Scientific Research Project Cultivation Fund of Huanghuai University[XKPY202004] ; Rongqiang Li acknowledges Zhumadian industrial Innovation and Development Research Project[2020ZDWT07]

Chemistry

Chemistry, Physical

WOS:000832693300004

ELSEVIER

20221812056645

Bacteria ; Carbonate minerals ; Fluorescence ; Gas generators ; Infrared devices ; Iridium ; Oxygen ; Photodynamic therapy

Medicine and Pharmacology:461.6 ; Minerals:482.2 ; Gas Fuels:522 ; Precious Metals:547.1 ; Light/Optics:741.1 ; Chemical Products Generally:804

CHEMISTRY

2-s2.0-85129097615

Web of Science

1.College of Chemistry and Pharmaceutical Engineering,Huanghuai University,Zhumadian,463000,China
2.Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China
3.Department of Chemistry,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Blvd.,518055,China

Liu，Chuangjun,Xiang，Jingjing,Li，Jing,et al. Rational design and synthesis of novel NIR photosensitizers and application in antimicrobial photodynamic inactivation[J]. JOURNAL OF MOLECULAR STRUCTURE,2022,1263.

Liu，Chuangjun.,Xiang，Jingjing.,Li，Jing.,Xiang，Chunbai.,Li，Huacheng.,...&Gong，Ping.(2022).Rational design and synthesis of novel NIR photosensitizers and application in antimicrobial photodynamic inactivation.JOURNAL OF MOLECULAR STRUCTURE,1263.

Liu，Chuangjun,et al."Rational design and synthesis of novel NIR photosensitizers and application in antimicrobial photodynamic inactivation".JOURNAL OF MOLECULAR STRUCTURE 1263(2022).