Epidemiology and Antimicrobial Resistance Profiles of the Nocardia Species in China, 2009 to 2021

Wang，Hao1; Zhu，Yue2; Cui，Qiaozhen3; Wu，Wenming3; Li，Gang4; Chen，Dongke5; Xiang，Lili6; Qu，Jiuxin7; Shi，Dongyan8; Lu，Binghuai2

2022-04-01

10.1128/spectrum.01560-21

Microbiology Spectrum   影响因子和分区

2165-0497

2165-0497

The genus Nocardia includes ubiquitous environmental saprophytes and the most frequently isolated aerobic actinomycete human pathogen responsible for localized or disseminated infection. Herein, the species distribution and antimicrobial susceptibility profiles of 441 nonrepetitive Nocardia strains are reported, collected from 21 provinces/cities in China over 13 years (from 2009 to 2021). These isolates were identified to species level by mass spectrometry or targeted DNA sequencing. The susceptibility profiles of Nocardia species for 15 antibiotics were determined by the broth microdilution method. Among these Nocardia isolates, Nocardia farcinica was the most commonly isolated species (39.9%, 176 of 441), followed by Nocardia cyriacigeorgica (28.6%, 126), Nocardia abscessus (6.6%, 29), and Nocardia otitidiscaviarum (5.9%, 26). Furthermore, 361 Nocardia strains (81.9%) were collected from lower respiratory tract (sputum, lung tissue, and bronchoalveolar lavage fluid), 50 (11.3%) were collected from skin and soft tissues, 9 were collected from blood, 9 were collected from eye, 4 were collected from cerebrospinal fluid and brain abscesses, and 2 were collected from pleural effusion. All of the Nocardia strains were susceptible to linezolid, followed by amikacin (99.3%) and trimethoprim-sulfamethoxazole (TMP-SMX) (99.1%). The antibiotic resistance profiles of other antibiotics varied tremendously among different Nocardia species. This demonstrated that accurate species identification and/or antibiotic susceptibility testing should be performed before the usage of these antibiotics. In summary, this is the largest study on the species and antibiotic resistance profiles of the genus Nocardia circulating in China, and our data will contribute to a better understanding of clinical nocardiosis. IMPORTANCE The genus Nocardia has the potential to cause nocardiosis, which might be underrecognized and underdiagnosed. Herein, the demographical features of 441 nonrepetitive nocardiosis cases and species distribution of their Nocardia strains in China, 2009 to 2021, are summarized. The susceptibility profiles for 15 antibiotics against all of the above Nocardia strains were also determined by the broth microdilution method. To date, this is the largest study on the genus Nocardia contributing to nocardiosis in China. Our study will be helpful for understanding the species diversity of Nocardia isolates distributed in China and for decision-making in the context of nocardiosis diagnosis and treatment.

genetic diversity Nocardia nocardiosis species distribution trimethoprim-sulfamethoxazole

SCI

英语

其他

China-Japan Friendship Hospital[2020-102-K66];Institute for Health Care Improvement[2020-2-4062];Sanming Project of Medicine in Shenzhen[SZSM201911009];

Microbiology

Microbiology

WOS:000835142100095

AMER SOC MICROBIOLOGY

2-s2.0-85127475058

Scopus

1.Department of Clinical Laboratory,Baoding People’s Hospital,Baoding,China
2.Laboratory of Clinical Microbiology and Infectious Diseases,Department of Pulmonary and Critical Care Medicine,China-Japan Friendship Hospital,Beijing,China
3.Department of Clinical Laboratory,Shanxi Provincial People’s Hospital,Taiyuan,China
4.Department of Clinical Laboratory,General Hospital of Ningxia Medical University,Yinchuan,China
5.Department of Clinical Laboratory,Beijing Hospital,Beijing,China
6.Department of Laboratory Medicine,Chongqing Shapingba District Chenjiaqiao Hospital,Affiliated Hospital of Chongqing Medical and Pharmaceutical College,Chongqing,China
7.Department of Clinical Laboratory,Shenzhen Third People's Hospital,Southern University of Science and Technology,National Clinical Research Center for Infectious Diseases,Shenzhen,China
8.Department of Clinical Laboratory,The Second Hospital of Hebei Medical University,Shijiazhuang,China

Wang，Hao,Zhu，Yue,Cui，Qiaozhen,et al. Epidemiology and Antimicrobial Resistance Profiles of the Nocardia Species in China, 2009 to 2021[J]. Microbiology Spectrum,2022,10(2).

Wang，Hao.,Zhu，Yue.,Cui，Qiaozhen.,Wu，Wenming.,Li，Gang.,...&Lu，Binghuai.(2022).Epidemiology and Antimicrobial Resistance Profiles of the Nocardia Species in China, 2009 to 2021.Microbiology Spectrum,10(2).

Wang，Hao,et al."Epidemiology and Antimicrobial Resistance Profiles of the Nocardia Species in China, 2009 to 2021".Microbiology Spectrum 10.2(2022).