Association of circulating branched-chain amino acids with risk of cardiovascular disease: A systematic review and meta-analysis

Wang，Yaqin1; Huang，Keyong1; Liu，Fangchao1; Lu，Xiangfeng1; Huang，Jianfeng1; Gu，Dongfeng1,2

2022-06-01

10.1016/j.atherosclerosis.2022.04.026

ATHEROSCLEROSIS   影响因子和分区

0021-9150

1879-1484

Background and aims: We conducted a systematic review with meta-analysis of non-prospective and prospective clinical studies to assess the effects of circulating branched-chain amino acids (BCAA), including Isoleucine, Valine and Leucine, on cardiovascular disease (CVD) risk. Methods: PubMed, Embase, Cochrane and CNKI databases were searched for publications reporting the relationship between BCAAs and CVD. Relative risk (RR) and odd ratios (OR) were extracted and pooled. Subgroup analysis and meta-regression were performed to identify potential sources of heterogeneity, sensitivity analysis was conducted to assess the robustness of pooled estimates. Results: 11 non-prospective studies involving 2806 participants and 10 prospective studies involving 43,895 participants reported correlations between BCAAs and CVD risk. Levels of circulating BCAAs changed in individuals with CVD compared with those in the control group. Nine prospective studies were meta-analyzed and highlighted a 10% higher risk of CVD per study-specific SD difference for Isoleucine (pooled relative risk 1.10 [1.03–1.18]; I = 63.5%). Valine and Leucine do not appear to be associated with CVD incidence. Subgroup analysis based on age suggested that among adults ≤60 years, there is a 15%, 13%, and 9% higher risk of developing CVD per study-specific SD difference for Isoleucine (RR 1.15 [1.11–1.19]; I = 0.0%), Valine (RR 1.13 [1.09–1.17]; I = 0.0%), and Leucine (RR 1.09 [1.03–1.16]; I = 40.5%), respectively. No such associations were observed for adults older than 60 years. Conclusions: Evidence suggests that elevated concentrations of circulating Isoleucine were associated with increased risks of CVD, independent of traditional risk factors.

Branched-chain amino acids Cardiovascular disease Epidemiology Meta-analysis

SCI

英语

通讯

Chinese Academy of Medical Sciences[2019RU038];National Natural Science Foundation of China[82030102];

Cardiovascular System & Cardiology

Cardiac & Cardiovascular Systems ; Peripheral Vascular Disease

WOS:000804975200002

ELSEVIER IRELAND LTD

CLINICAL MEDICINE

2-s2.0-85129930203

Scopus

1.Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Cardiovascular Epidemiology,Chinese Academy of Medical Sciences,Beijing,10037,China
2.School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China

Wang，Yaqin,Huang，Keyong,Liu，Fangchao,et al. Association of circulating branched-chain amino acids with risk of cardiovascular disease: A systematic review and meta-analysis[J]. ATHEROSCLEROSIS,2022,350:90-96.

Wang，Yaqin,Huang，Keyong,Liu，Fangchao,Lu，Xiangfeng,Huang，Jianfeng,&Gu，Dongfeng.(2022).Association of circulating branched-chain amino acids with risk of cardiovascular disease: A systematic review and meta-analysis.ATHEROSCLEROSIS,350,90-96.

Wang，Yaqin,et al."Association of circulating branched-chain amino acids with risk of cardiovascular disease: A systematic review and meta-analysis".ATHEROSCLEROSIS 350(2022):90-96.