PtBi-β-CD-Ce6 Nanozyme for Combined Trimodal Imaging-Guided Photodynamic Therapy and NIR-II Responsive Photothermal Therapy

Xie，Yulin1; Wang，Man1; Sun，Qianqian1; Wang，Dongmei2; Luo，Shuiping3; Li，Chunxia1

2022

10.1021/acs.inorgchem.2c00168

INORGANIC CHEMISTRY   影响因子和分区

0020-1669

1520-510X

Combined photothermal/photodynamic therapy is a promising strategy to achieve an enhanced anticancer effect. However, hypoxia is one of the representative characteristics of the microenvironment of solid tumors, which not only attenuates the therapeutic effects but also promotes tumor invasion and metastasis. Herein, a PtBi-β-CD-Ce6 nanoplatform for the generation of sustained O2 was constructed for more effective tumor therapy. In detail, the catalase (CAT)-like nanozyme, PtBi, which could decompose H2O2 to produce O2, was modified with β-cyclodextrin (β-CD). O2 would be converted into 1O2 by PtBi-β-CD-Ce6 for enhanced photodynamic therapy (PDT) under 650 nm laser irradiation. In addition, by reason of excellent absorption in the near-infrared-II (NIR-II) region, PtBi-β-CD-Ce6 was used for photoacoustic imaging (PA) and photothermal imaging (PT)-guided photothermal therapy (PTT) in the NIR-II biowindow. Furthermore, PtBi-β-CD-Ce6 could be elected to serve as a contrast agent for X-ray computed tomography (CT) imaging due to the apparent X-ray attenuation capability of the Pt and Bi elements themselves. Therefore, by integrating the advantages of overcoming the hypoxia function and photothermal effect into a single nanoplatform, PtBi-β-CD-Ce6 showed an immense possibility in multimodal imaging-guided combined PDT/PTT.

SCI ; EI

英语

NI论文

通讯

National Natural Science Foundation of China[51872263,52102189] ; Taishan Scholars Project[ts20190911] ; Shandong Natural Science Foundation[ZR2020ZD36] ; Guang Natural Science Foundation[2022A1515010461]

Chemistry

Chemistry, Inorganic & Nuclear

WOS:000797994700017

AMER CHEMICAL SOC

20222012119339

Computerized tomography ; Photodynamic therapy ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Computer Applications:723.5

CHEMISTRY

2-s2.0-85130001455

Scopus

1.Institute of Molecular Sciences and Engineering,Institute of Frontier and Interdisciplinary Science,Shandong University,Qingdao,266237,China
2.Key Laboratory of the Ministry of Education for Advanced Catalysis Materials,College of Chemistry and Life Sciences,Zhejiang Normal University,Jinhua,321004,China
3.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China

Xie，Yulin,Wang，Man,Sun，Qianqian,et al. PtBi-β-CD-Ce6 Nanozyme for Combined Trimodal Imaging-Guided Photodynamic Therapy and NIR-II Responsive Photothermal Therapy[J]. INORGANIC CHEMISTRY,2022,61(18).

Xie，Yulin,Wang，Man,Sun，Qianqian,Wang，Dongmei,Luo，Shuiping,&Li，Chunxia.(2022).PtBi-β-CD-Ce6 Nanozyme for Combined Trimodal Imaging-Guided Photodynamic Therapy and NIR-II Responsive Photothermal Therapy.INORGANIC CHEMISTRY,61(18).

Xie，Yulin,et al."PtBi-β-CD-Ce6 Nanozyme for Combined Trimodal Imaging-Guided Photodynamic Therapy and NIR-II Responsive Photothermal Therapy".INORGANIC CHEMISTRY 61.18(2022).