ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis

Xiao, Yu1; Deng, Zhiqin2; Li, Yongshen2; Wei, Baoting2; Chen, Xiaoqiang2; Zhao, Zhe2; Xiu, Yingjie4; Hu, Meifang4; Alahdal, Murad2; Deng, Zhenhan3; Wang, Daping2,5; Liu, Jianquan2; Li, Wencui2

2022-05-16

10.1186/s12935-022-02611-0

CANCER CELL INTERNATIONAL   影响因子和分区

1475-2867

Objectives To screen and verify differential genes affecting the prognosis of breast cancer. Methods Breast cancer gene expression datasets were downloaded from the GEO database, and original data were analyzed in R. The TIMER database was used to analyze the relationship between ANLN and UBE2T and immune cell infiltration. Results Ten hub-key genes were identified, and survival analysis showed that UBE2T and ANLN were upregulated in breast cancer and their upregulation was associated with a poor prognosis. ANLN and UBE2T upregulation was associated with the prevalence of Th1 and Th2 cells, shifting the Th1/Th2 balance to Th2 in Basal and Luminal-B breast cancers, which indicates a poor prognosis (P < 0.05). Conclusion ANLN and UBE2T are potential biomarkers for predicting the prognosis of breast cancer.

Breast cancer Luminal type of breast cancer Prognostic biomarkers Immune regulation T cells

SCI

英语

其他

National Natural Science Foundation of China[81800785,81972085] ; Natural Science Foundation of Guangdong Province["2018A0303100027","2021A1515010706"] ; Guangdong Provincial Key Clinical Discipline-Orthopedics[2000005] ; Shenzhen Fund for Guangdong Provincial Highlevel Clinical Key Specialties[SZGSP007] ; Sanming Project of Shenzhen Health and Family Planning Commission[SZSM201612086] ; Shenzhen Science and Technology Planning["JCYJ20180228163401333","JCYJ20190806170612680"] ; Shenzhen Key Medical Discipline Construction Fund[SZXK025] ; discipline construction Capacity Improvement project of Shenzhen Municipal Health Commission[SZXJ2018065]

Oncology

Oncology

WOS:000796571600003

BMC

2-s2.0-85131018316

Web of Science

1.Shenzhen Univ, Dept Breast & Thyroid Surg, Shenzhen Peoples Hosp 2, Hosp Affiliated 1, Shenzhen 518000, Peoples R China
2.Shenzhen Univ, Hand & Foot Surg Dept, Shenzhen Peoples Hosp 2, Hosp Affiliated 1, 3002 Sungang West Rd, Shenzhen 518000, Peoples R China
3.Shenzhen Univ, Dept Sports Med, Shenzhen Peoples Hosp 2, Hlth Sci Ctr,Hosp Affiliated 1, Shenzhen 518000, Peoples R China
4.Shenzhen Univ, Dept Pathol, Shenzhen Peoples Hosp 2, Hosp Affiliated 1, Shenzhen 518000, Peoples R China
5.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China

Xiao, Yu,Deng, Zhiqin,Li, Yongshen,et al. ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis[J]. CANCER CELL INTERNATIONAL,2022,22(1).

Xiao, Yu.,Deng, Zhiqin.,Li, Yongshen.,Wei, Baoting.,Chen, Xiaoqiang.,...&Li, Wencui.(2022).ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis.CANCER CELL INTERNATIONAL,22(1).

Xiao, Yu,et al."ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis".CANCER CELL INTERNATIONAL 22.1(2022).