南方科技大学知识苑(SUSTech KC): The Relationship Between Hepcidin-Mediated Iron Dysmetabolism and COVID-19 Severity: A Meta-Analysis

题名	The Relationship Between Hepcidin-Mediated Iron Dysmetabolism and COVID-19 Severity: A Meta-Analysis
作者	Peng, Denggao 1,2; Gao, Yanzhang 1; Zhang, Li1 ; Liu, Zhichao 1; Wang, Huan1 ; Liu, Yingxia 1,2
通讯作者	Liu, Yingxia
发表日期	2022-04-26
DOI	10.3389/fpubh.2022.881412
发表期刊	FRONTIERS IN PUBLIC HEALTH 影响因子和分区
EISSN	2296-2565
卷号	10
摘要	Backgrounds: Hepcidin has been identified as a systemic iron-regulatory hormone. Recent studies have suggested that iron metabolism disorders may be involved in the pathogenesis of acute respiratory distress syndrome and multiple organ dysfunction in coronavirus disease 2019 (COVID-19).& nbsp;Objectives: To re-evaluate the hepcidin-related iron metabolism parameters and explore the relationship between hepcidin-mediated iron dysmetabolism and COVID-19 severity.& nbsp;Methods: COVID-19 is classified as mild and moderate as non-severe, severe and critical as severe. A meta-analysis was conducted. Four bibliographic databases were comprehensively searched up to December 31st 2021.& nbsp;Results: Six unique studies with data from 477 COVID-19 patients were included. Compared to non-severe cases, severe cases had higher hepcidin (standardized mean difference (SMD), -0.39; 95% Confidence Interval (CI) [-0.76, -0.03]; P = 0.03) and ferritin (SMD, -0.84; 95% CI [-1.30, -0.38]; P = 0.0004). In five out of six studies, a total of 427 patients were tested for serum iron, and there were significant differences in their levels between severe and non-severe cases (SMD, 0.22; 95% CI [0.02, 0.41]; P = 0.03). A total of 320 patients from four out of six studies were tested for transferrin saturation, and the statistical difference was not significant (SMD, 0.06; 95% CI [-0.17, 0.28]; P = 0.64).& nbsp;Conclusion: Severe COVID-19 cases had higher serum levels of hepcidin and ferritin, and lower serum iron, without significant differences in transferrin saturation. Further studies are needed to verify whether targeting the hepcidin-mediated iron metabolism axis may influence the outcome and treatment of COVID-19.
关键词	COVID-19 ferritin hepcidin iron metabolism severity
相关链接	[来源记录]
收录类别	SCI ; SSCI
语种	英语
学校署名	第一 ; 通讯
WOS研究方向	Public, Environmental & Occupational Health
WOS类目	Public, Environmental & Occupational Health
WOS记录号	WOS:000795686400001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计	被引频次[WOS]：11
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/335017
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Hosp 2, Shenzhen, Peoples R China 2.Univ South China, Grad Collaborat Training Base Shenzhen Peoples Hos, Hengyang Med Sch, Hengyang, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Peng, Denggao,Gao, Yanzhang,Zhang, Li,et al. The Relationship Between Hepcidin-Mediated Iron Dysmetabolism and COVID-19 Severity: A Meta-Analysis[J]. FRONTIERS IN PUBLIC HEALTH,2022,10.
APA	Peng, Denggao,Gao, Yanzhang,Zhang, Li,Liu, Zhichao,Wang, Huan,&Liu, Yingxia.(2022).The Relationship Between Hepcidin-Mediated Iron Dysmetabolism and COVID-19 Severity: A Meta-Analysis.FRONTIERS IN PUBLIC HEALTH,10.
MLA	Peng, Denggao,et al."The Relationship Between Hepcidin-Mediated Iron Dysmetabolism and COVID-19 Severity: A Meta-Analysis".FRONTIERS IN PUBLIC HEALTH 10(2022).