Dating the origin and dispersal of global hepatitis B virus genotype C in humans

Li, Tianze1; Chen, Hui2; Sun, Liqin3; Liu, Jiaye4,5

2022-04-01

10.5582/ddt.2022.01030

Drug Discoveries and Therapeutics   影响因子和分区

1881-7831

1881-784X

Hepatitis B virus genotype C (HBV/C) is one of the most prevalent HBV strains worldwide, especially in the Western Pacific and the South-East Asia. However, the origin and evolutionary timescale of HBV/C remains largely unresolved. We analyzed the evolutionary rate and molecular clock phylogeny of 101 full-genomc HBV/C sequences sampled globally using a Bayesian Markov Chain Monte Carlo (MCMC) approach. We inferred the spatiotemporal dynamics of the HBV/C worldwide by the Bayesian Stochastic Search Variable Selection (BSSVS). We found that the estimated mean evolution rate of the HBV/C genotype full-genome was 4.32 x 10(-5) subs/site/year (95% highest posterior density 3.02 x 10(-6) - 8.97 x 10(-5)). Phylogeographic reconstruction was able to identify a single location for the origin of the global HBV/C in Australia around A.D. 715. The subgcnotype C4 diverged earliest and mainly circulated in Australia, Cl mainly in Southeast Asia, C2 mainly in East Asia and C3 in Remote Oceania. The effective nwnber of HBV infection presented a rapid exponential increase between the 1760s and 1860s followed by a maintained high level until now. Our study, for the first time, provides an estimated timescale for the HBV/C epidemic, and brings new insight to the dispersal of HBV/C in humans globally. Based on the continuous presence of a highly effective viral population, this study provides further evidence of the challenge from a population-based molecular level to eliminate HBV by 2030, and calls for a concerted effort from policy makers, health providers, and society in the globalized world.

Hepatitis B virus HBV genotype C evolution phylogenctic phylogeographic

ESCI

英语

其他

National Natural Science Foundation of China[81803299] ; Natural Science Foundation of Shandong Province, China[ZR2019PH046]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000795504500006

INT RESEARCH & COOPERATION ASSOC BIO & SOCIO-SCIENCES ADVANCEMENT

Web of Science

1.Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Hlth Stat, Zhengzhou, Henan, Peoples R China
2.Ctr Dis Control & Prevent Chinese Peoples Liberat, Beijing, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China
4.Shenzhen Univ, Sch Publ Hlth, Hlth Sci Ctr, Shenzhen 518060, Peoples R China
5.Shandong Prov Ctr Dis Control & Prevent, Expanded Program Immunizat Div, Jinan, Peoples R China

Li, Tianze,Chen, Hui,Sun, Liqin,et al. Dating the origin and dispersal of global hepatitis B virus genotype C in humans[J]. Drug Discoveries and Therapeutics,2022,16(2).

Li, Tianze,Chen, Hui,Sun, Liqin,&Liu, Jiaye.(2022).Dating the origin and dispersal of global hepatitis B virus genotype C in humans.Drug Discoveries and Therapeutics,16(2).

Li, Tianze,et al."Dating the origin and dispersal of global hepatitis B virus genotype C in humans".Drug Discoveries and Therapeutics 16.2(2022).