南方科技大学知识苑(SUSTech KC): Dose of intra-operative opioids has no impact on recurrence or survival in primary liver cancer

题名	Dose of intra-operative opioids has no impact on recurrence or survival in primary liver cancer
作者	Zhao, Liuyuan 1; Teng, Lei 1; Zhang, Wenhui 1; Lin, Shiyan 1; Liu, Xuejiao 1; Dai, Junzhu 1; Shao, Hongxue 1; Li, Xiaoshi 2; Liu, Quan2 ; Zou, Huichao 1
通讯作者	Zou, Huichao
发表日期	2022-05-01
DOI	10.1002/cam4.4827
发表期刊	Cancer Medicine 影响因子和分区
ISSN	2045-7634
摘要	Background Intra-operative use of opioid analgesics might have an impact on cancer recurrence and survival after surgery. The objective of this study was to investigate the association between the intra-operative fentanyl equivalents and survival outcomes in patients with primary liver cancer after receiving hepatectomy. Methods This was a retrospective single-center cohort study, and clinical data of 700 patients with primary liver cancer who underwent hepatectomy in Harbin Medical University Cancer Hospital from September 2013 to August 2018 were reviewed. After propensity matching, 376 patients were included. Patients were divided into high-dose and low-dose groups according to the median intra-operative fentanyl equivalents (1.500 mg). Kaplan Meier curve and Cox proportional hazards regression model were used. Results Results of univariable analysis showed there were no significant differences in recurrence-free survival (RFS) (p = 0.136) and overall survival (OS) (p = 0.444) between high-dose fentanyl equivalents and low-dose fentanyl equivalents group. The multivariable Cox regression analysis found that the dose of intra-operative fentanyl equivalents was not associated with RFS (HR: 1.119, 95%CI: 0.851-1.472, p = 0.422) or OS (HR: 0.939, 95%CI: 0.668-1.319, p = 0.715). Conclusions The amounts of intra-operative fentanyl equivalents had no impact on recurrence-free or overall survival in patients with primary liver cancer after curative hepatectomy.
关键词	hepatectomy intro-operative opioid overall survival primary liver cancer recurrence-free survival
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000797380500001
出版者	WILEY
来源库	Web of Science
引用统计	被引频次[WOS]：2
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/335178
专题	南方科技大学医学院_生物化学系南方科技大学医学院
作者单位	1.Harbin Med Univ, Dept Pain Med, Canc Hosp, Harbin, Peoples R China 2.Southern Univ Sci & Technol, Sch Med, Dept Biochem, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Liuyuan,Teng, Lei,Zhang, Wenhui,et al. Dose of intra-operative opioids has no impact on recurrence or survival in primary liver cancer[J]. Cancer Medicine,2022.
APA	Zhao, Liuyuan.,Teng, Lei.,Zhang, Wenhui.,Lin, Shiyan.,Liu, Xuejiao.,...&Zou, Huichao.(2022).Dose of intra-operative opioids has no impact on recurrence or survival in primary liver cancer.Cancer Medicine.
MLA	Zhao, Liuyuan,et al."Dose of intra-operative opioids has no impact on recurrence or survival in primary liver cancer".Cancer Medicine (2022).