Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer

Zhang, Zhiqin1; Wang, Kaixin1; Liu, Manting1; Hu, Panxiang1; Xu, Yuchen1; Yin, Dongge1; Yang, Yuchang1; Dong, Xiaoxv1; Qu, Changhai1; Zhang, Lu2; Ni, Jian1; Yin, Xingbin1

2022-12-31

10.1080/10717544.2022.2075987

DRUG DELIVERY   影响因子和分区

1071-7544

1521-0464

Photodynamic therapy (PDT) and photothermal therapy (PTT) have attracted research interest for their noninvasive nature and selective treatment of tumor tissues. They are effective through the generation of reactive oxygen species (ROS) or heat. Nevertheless, several problems, including low bioavailability and long-lasting cutaneous photosensitivity, have limited their clinical application. In this study, we reported an in situ self-assembly strategy that could improve various biological properties of the photosensitizer in vivo. A photosensitizer connected to a receptor-mediated smart peptide can self-assemble into nanoparticles (NPs) under the force of hydrophobic interaction and then transform into a nanofibrillar network after attaching to the tumor cell surface with the help of the beta-sheet-forming peptide KLVFF. The supramolecular structural changes deeply affected the PDT and PTT properties of the photosensitizer on tumors. After being aggregated into the nanostructure, the water solubility and targeting ability of the photosensitizer was ameliorated. Moreover, the improvement of the photothermal conversion efficiency, ROS generation, and tumor retention followed the formation of nanofibrils (NFs). This self-assembly strategy showed the ability of supramolecular nanofibrils to improve the bioavailability of photosensitizers, which provides a new potential treatment avenue for various cancer therapies.

Phototherapy self-assembled peptide supramolecular nanofibrils bioavailability improvement photothermal conversion efficiency

SCI

英语

通讯

Fundamental Research Funds for the Central Universities[2020-JYB-ZDGG-046]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000800055200001

TAYLOR & FRANCIS LTD

PHARMACOLOGY & TOXICOLOGY

Web of Science

1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Zhang, Zhiqin,Wang, Kaixin,Liu, Manting,et al. Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer[J]. DRUG DELIVERY,2022,29(1).

Zhang, Zhiqin.,Wang, Kaixin.,Liu, Manting.,Hu, Panxiang.,Xu, Yuchen.,...&Yin, Xingbin.(2022).Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer.DRUG DELIVERY,29(1).

Zhang, Zhiqin,et al."Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer".DRUG DELIVERY 29.1(2022).