The role of cell-penetrating peptides in potential anti-cancer therapy

Zhou, Meiling1,2; Zou, Xi1,2; Cheng, Kexin1,2; Zhong, Suye1,2; Su, Yangzhou1,2; Wu, Tao1,2; Tao, Yongguang3; Cong, Li1,2; Yan, Bin4; Jiang, Yiqun1,2

2022-05-01

10.1002/ctm2.822

Clinical and Translational Medicine   影响因子和分区

2001-1326

Due to the complex physiological structure, microenvironment and multiple physiological barriers, traditional anti-cancer drugs are severely restricted from reaching the tumour site. Cell-penetrating peptides (CPPs) are typically made up of 5-30 amino acids, and can be utilised as molecular transporters to facilitate the passage of therapeutic drugs across physiological barriers. Up to now, CPPs have widely been used in many anti-cancer treatment strategies, serving as an excellent potential choice for oncology treatment. However, their drawbacks, such as the lack of cell specificity, short duration of action, poor stability in vivo, compatibility problems (i.e. immunogenicity), poor therapeutic efficacy and formation of unwanted metabolites, have limited their further application in cancer treatment. The cellular uptake mechanisms of CPPs involve mainly endocytosis and direct penetration, but still remain highly controversial in academia. The CPPs-based drug delivery strategy could be improved by clever design or chemical modifications to develop the next-generation CPPs with enhanced cell penetration capability, stability and selectivity. In addition, some recent advances in targeted cell penetration that involve CPPs provide some new ideas to optimise CPPs.

Anti-cancer therapy cell-penetrating peptides molecular cargoes optimisation tumour immunity

SCI

英语

通讯

National Natural Science Foundation of China[81802785,82100490,81802658] ; Hunan Provincial Natural Science Foundation of China["2020JJ5382","2020JJ5381"] ; Scientific Research Project of Hunan Provincial Health Commission[202202065445] ; Hunan Normal University undergraduates innovative experiment project and entrepreneurship program[2021029]

Oncology ; Research & Experimental Medicine

Oncology ; Medicine, Research & Experimental

WOS:000798834300001

JOHN WILEY & SONS LTD

Web of Science

1.Hunan Normal Univ, Key Lab Model Anim & Stem Cell Biol Hunan Prov, Changsha 410013, Hunan, Peoples R China
2.Hunan Normal Univ, Sch Med, Changsha, Hunan, Peoples R China
3.Cent South Univ, Xiangya Hosp, Sch Basic Med,Minist Educ, Dept Pathol,Key Lab Carcinogenesis & Canc Invas, Changsha, Hunan, Peoples R China
4.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Pathol,Clin Med Coll 2,Affiliated Hosp 1, Shenzhen 518020, Peoples R China

Zhou, Meiling,Zou, Xi,Cheng, Kexin,et al. The role of cell-penetrating peptides in potential anti-cancer therapy[J]. Clinical and Translational Medicine,2022,12(5).

Zhou, Meiling.,Zou, Xi.,Cheng, Kexin.,Zhong, Suye.,Su, Yangzhou.,...&Jiang, Yiqun.(2022).The role of cell-penetrating peptides in potential anti-cancer therapy.Clinical and Translational Medicine,12(5).

Zhou, Meiling,et al."The role of cell-penetrating peptides in potential anti-cancer therapy".Clinical and Translational Medicine 12.5(2022).