Surface modification of polyetheretherketone (PEEK) to enhance osteointegration by grafting strontium Eucommia ulmoides polysaccharides

Mengdi，Zhang1; Jiayi，Liu2; Canfeng，Li1; Guofeng，Wu2; Yutong，Wu2; Pengzhou，Huang1; Yikun，Zhao1; Xintao，Zhang1; Bin，Tang2,3,4

2022-06-30

10.1016/j.ijbiomac.2022.05.048

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES   影响因子和分区

0141-8130

1879-0003

The complex bone regeneration microenvironment puts high demands on orthopedic implants. The implants are not only desired to satisfy the meeting of the biomechanical properties, but should also possess capabilities to promote osseointegration and bone immune regulation. PEEK is a promising polymeric material for bone implants due to its suitable mechanical properties that well match natural cortical bone tissue. However, its inert biological properties limit its application. As a newly-developed bioactive polysaccharides complex, strontium Eucommia ulmoides polysaccharides (EUP-Sr) has been proved to have capabilities including promoting osteogenesis and regulating bone immunity. In this study, in order to improve the bioactivities of PEEK, we introduce EUP-Sr to the PEEK surface via polydopamine-based coating and form a bioactive PEEK named DPEEK@EUP-Sr. The as-fabricated DPEEK@EUP-Sr was systematically investigated through scanning electron microscopy, X-ray photoelectron spectroscopy, water contact angle analysis to verify the successful introduction of EUP-Sr to PEEK, and in vitro biological experiments including cell proliferation and RT-PCR analysis suggested that the DPEEK@EUP-Sr can effectively promote the proliferation of preosteoblast MC3T3-E1, and exhibit significant anti-inflammation and osteogenesis effects, and so should be beneficial for osteointegration between bone and implants.

Anti-inflammation EUP-Sr Osteogenesis Osteointegration PEEK

英语

通讯

National Key Research and Development Program of China[2019YFA0906004];

BIOLOGY & BIOCHEMISTRY

2-s2.0-85130207100

Scopus

1.Department of Sports Medicine and Rehabilitation,Peking University Shenzhen,Shenzhen,Guangdong,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,China
3.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,China
4.Shenzhen Key Laboratory of Cell Microenvironment,PR China Hospital,Shenzhen,Guangdong,China

Mengdi，Zhang,Jiayi，Liu,Canfeng，Li,et al. Surface modification of polyetheretherketone (PEEK) to enhance osteointegration by grafting strontium Eucommia ulmoides polysaccharides[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2022,211:230-237.

Mengdi，Zhang.,Jiayi，Liu.,Canfeng，Li.,Guofeng，Wu.,Yutong，Wu.,...&Bin，Tang.(2022).Surface modification of polyetheretherketone (PEEK) to enhance osteointegration by grafting strontium Eucommia ulmoides polysaccharides.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,211,230-237.

Mengdi，Zhang,et al."Surface modification of polyetheretherketone (PEEK) to enhance osteointegration by grafting strontium Eucommia ulmoides polysaccharides".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 211(2022):230-237.