Preliminary Interpretations of Epigenetic Profiling of Cord Blood in Preeclampsia

Ma，Junrui1,2; Zhan，Zhongqun3; Li，Ning4; Huang，Yanli5; Li，Yan5; Liu，Lu5; Shen，Qi3; Chu，Qiao1; Wang，Xiaonan1; Wu，Benqing3,6; Zhang，Hui3

2022-05-01

10.3390/genes13050888

Genes   影响因子和分区

2073-4425

Preeclampsia (PE) is characterized by new-onset hypertension after 20 weeks of pregnancy and results in high maternal and fetal mortality worldwide. It has been reported that PE is associated with abnormalities in the umbilical cord and cord blood. However, previous studies were focused primarily on the transcriptomics level, while the underlying gene regulatory landscapes are still unclear. Thus, we performed the Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) using the umbilical cord blood samples collected from a patient with super-imposed PE and three healthy donors to uncover the chromatin accessibility changes attributed to PE. We have identified genes associated with immunomodulation and hypoxia response that have higher chromatin accessibility close to their transcription start sites. Motif analysis indicated that the GATA family transcription factor binding was enriched in PE and may play an essential regulatory role in the disease progression. Overall, our findings provide an overview of gene regulatory programs and the corresponding downstream pathways associated with PE that may influence the placenta function and fetal growth.

epigenetic alternation GATA family transcription factor hypoxia response immunomodulation preeclampsia

英语

其他

Natural Science Foundation of Guangdong Province[2019A1515011068];Natural Science Foundation of Guangdong Province[2020A1515010714];National Natural Science Foundation of China[72004133];

2-s2.0-85130697500

Scopus

1.School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,200025,China
2.Faculty of Medical Laboratory Science,College of Health Science and Technology,Shanghai Jiao Tong University School of Medicine,Shanghai,200025,China
3.Institute of Translational Medicine,University of Chinese Academy of Sciences Shenzhen Hospital,Shenzhen,518106,China
4.Cytotherapy Laboratory,The First Affiliated Hospital (Shenzhen People’s Hospital) Southern University of Science and Technology,Shenzhen,518020,China
5.Department of Obstetrics,University of Chinese Academy of Sciences Shenzhen Hospital,Shenzhen,518106,China
6.Department of Neonatology,Shenzhen Guangming Maternity & Child Healthcare Hospital,Shenzhen,518107,China

Ma，Junrui,Zhan，Zhongqun,Li，Ning,et al. Preliminary Interpretations of Epigenetic Profiling of Cord Blood in Preeclampsia[J]. Genes,2022,13(5).

Ma，Junrui.,Zhan，Zhongqun.,Li，Ning.,Huang，Yanli.,Li，Yan.,...&Zhang，Hui.(2022).Preliminary Interpretations of Epigenetic Profiling of Cord Blood in Preeclampsia.Genes,13(5).

Ma，Junrui,et al."Preliminary Interpretations of Epigenetic Profiling of Cord Blood in Preeclampsia".Genes 13.5(2022).