Contemporary synthesis of bioactive cyclobutane natural products

Hui，Chunngai1,2; Wang，Zhuo5; Xie，Yusheng6; Liu，Junyang3,4

2022

10.1016/j.gresc.2022.04.006

Green Synthesis and Catalysis   影响因子和分区

2666-5549

Many cyclobutane natural products have intriguing biological properties that arise from their fascinating chemical structures. Cyclobutane natural products feature a cyclobutane scaffold as the core or as a part of the spirocyclic or fused cyclic core. However, the highly functionalized nature and the inherent stereochemistry of these cyclobutane natural products, which are associated with their biological activities, pose tremendous challenges to their preparation. In this perspective, we present contemporary advancements in synthetic methods and/or strategies en route to the bioactive cyclobutane natural products. We begin by describing the representative bioactive cyclobutane natural products and then focus on illustrative examples of their syntheses reported from 2018 to 2021. These advances will enable efficient syntheses of cyclobutanes of structural and biological importance.

Bioactive Chemical synthesis Cyclobutane Natural products Synthetic methodology

ESCI

英语

通讯

Basic and Applied Basic Research Foundation of Guangdong Province[2021A1515010188];National Natural Science Foundation of China[22107058];

Chemistry

Chemistry, Multidisciplinary

WOS:001022736200001

KEAI PUBLISHING LTD

2-s2.0-85130919360

Scopus

1.Max Planck Institute of Molecular Physiology,Department of Chemical Biology,Dortmund,44227,Germany
2.Technical University Dortmund,Faculty of Chemistry and Chemical Biology,Dortmund,44221,Germany
3.School of Biotechnology and Health Sciences,Wuyi University,Jiangmen,Guangdong,529020,China
4.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,518055,China
5.Southern University of Science and Technology,School of Medicine,Shenzhen,518005,China
6.Department of Pharmacology,School of Basic Medical Sciences,Shandong University,Jinan,250012,China

Hui，Chunngai,Wang，Zhuo,Xie，Yusheng,et al. Contemporary synthesis of bioactive cyclobutane natural products[J]. Green Synthesis and Catalysis,2022,4(1).

Hui，Chunngai,Wang，Zhuo,Xie，Yusheng,&Liu，Junyang.(2022).Contemporary synthesis of bioactive cyclobutane natural products.Green Synthesis and Catalysis,4(1).

Hui，Chunngai,et al."Contemporary synthesis of bioactive cyclobutane natural products".Green Synthesis and Catalysis 4.1(2022).