AIEgen-Based Bionic Nanozymes for the Interventional Photodynamic Therapy-Based Treatment of Orthotopic Colon Cancer

Duo，Yanhong1,6,7; Suo，Meng5; Zhu，Daoming5; Li，Zihuang1; Zheng，Zheng3,4; Tang，Ben Zhong2

2022

10.1021/acsami.2c04210

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

Relative to traditional photosensitizer (PS) agents, those that exhibit aggregation-induced emission (AIE) properties offer key advantages in the context of photodynamic therapy (PDT). At present, PDT efficacy is markedly constrained by the hypoxic microenvironment within tumors and the limited depth to which lasers can penetrate in a therapeutic context. Herein, we developed platelet-mimicking MnO2 nanozyme/AIEgen composites (PMD) for use in the interventional PDT treatment of hypoxic tumors. The resultant biomimetic nanoparticles (NPs) exhibited excellent stability and were able to efficiently target tumors. Moreover, they were able to generate O2 within the tumor microenvironment owing to their catalase-like activity. Notably, through an interventional approach in which an optical fiber was introduced into the abdominal cavity of mice harboring orthotopic colon tumors, good PDT efficacy was achieved. We thus propose that a novel strategy consisting of a combination of an AIEgen-based bionic nanozyme and a biomimetic cell membrane coating represents an ideal therapeutic platform for targeted antitumor PDT. This study is the first to have combined interventional therapy and AIEgen-based PDT, thereby overcoming the limited light penetration that typically constrains the therapeutic efficacy of this technique, highlighting a promising new AIEgen-based PDT treatment strategy.

aggregation-induced emission interventional photodynamic therapy orthotopic colon cancer platelet-mimicking MnO2nanozyme tumor targeting

SCI ; EI

英语

第一 ; 通讯

State Key Research Development Program of China[2019YFB2203503] ; National Natural Science Foundation of China[61875138,61435010,61961136001,22105057] ; Research Grants of Council of Hong Kong["N-HKUST609/19","C6009-17G","A-HKUST605/16"] ; Innovation of Technology Commission[ITC-CNERC14SC01]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000812430800001

AMER CHEMICAL SOC

2-s2.0-85130859905

Scopus

1.Department of Radiation Oncology,The Second Clinical Medical College of Jinan University,1st Affiliated Hospital of Southern University of Science and Technology,Shenzhen People's Hospital,Shenzhen,518020,China
2.School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen,Guangdong,518172,China
3.School of Chemistry and Chemical Engineering,Hefei University of Technology,Hefei,230009,China
4.AnHui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials,Anhui University,Hefei,230601,China
5.Department of Electronic Science and Technology,School of Physics and Technology,Wuhan University,Wuhan,430072,China
6.Department of Microbiology,Tumor and Cell Biology (MTC),Karolinska Institutet,Stockholm,17177,Sweden
7.Department of Sports Medicine and Rehabilitation,Shenzhen Hospital Peking University,Shenzhen,518036,China

Duo，Yanhong,Suo，Meng,Zhu，Daoming,et al. AIEgen-Based Bionic Nanozymes for the Interventional Photodynamic Therapy-Based Treatment of Orthotopic Colon Cancer[J]. ACS Applied Materials & Interfaces,2022,14(23).

Duo，Yanhong,Suo，Meng,Zhu，Daoming,Li，Zihuang,Zheng，Zheng,&Tang，Ben Zhong.(2022).AIEgen-Based Bionic Nanozymes for the Interventional Photodynamic Therapy-Based Treatment of Orthotopic Colon Cancer.ACS Applied Materials & Interfaces,14(23).

Duo，Yanhong,et al."AIEgen-Based Bionic Nanozymes for the Interventional Photodynamic Therapy-Based Treatment of Orthotopic Colon Cancer".ACS Applied Materials & Interfaces 14.23(2022).