| 题名 | Copper-Catalyzed Chan-Lam Coupling of NH-Diaryl Sulfondiimines |
| 作者 | |
| 通讯作者 | Zhu，Ning; Jia，Tiezheng |
| 发表日期 | 2022
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| DOI | |
| 发表期刊 | |
| ISSN | 1615-4150
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| EISSN | 1615-4169
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| 摘要 | Sulfondiimines, which contain a tetrasubstituted sulfur centre bearing two nitrogens and two carbon substituents, are a class of underexplored scaffolds in organic chemistry. Fascinated by some unique yet intriguing properties, sulfondiimines appear as leads in discovery industry, but the lack of efficient synthetic approaches holds back their further uptake by medicinal chemistry. Herein, a general and practical copper-catalyzed Chan-Lam coupling of NH-diaryl sulfondiimines with arylboronic acids is presented. A simple copper catalyst efficiently facilitated the highly chemoselective construction of C−N bond, allowing the preparation of a variety of N-arylated diaryl sulfondiimines in good yields under mild and environmentally benign conditions. An array of protecting groups on imine moieties were well tolerated, offering diversified accesses to NH,NAr-diaryl sulfondiimines, a class of versatile building blocks. Moreover, an aza-analogue of an EphB4 inhibitor featuring a sulfondiimine-based pharmacophore was generated employing our Chan-Lam coupling as the key step. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| WOS记录号 | WOS:000801035200001
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| Scopus记录号 | 2-s2.0-85130500141
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| 来源库 | Scopus
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| 引用统计 |
被引频次[WOS]：6
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/335515 |
| 专题 | 理学院_化学系 深圳格拉布斯研究院 |
| 作者单位 | 1.Chemical Engineering College,Inner Mongolia University of Technology,Hohhot,No. 49, Aimin Street, Xincheng District,010051,China 2.Shenzhen Grubbs Institute,Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Blvd, Guangdong,518055,China 3.State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin,94 Weijin Rd.,300071,China |
| 第一作者单位 | 化学系; 深圳格拉布斯研究院 |
| 通讯作者单位 | 化学系; 深圳格拉布斯研究院 |
| 推荐引用方式 GB/T 7714 |
Wang，Yangyang,Meng，Tingting,Su，Shuaisong,et al. Copper-Catalyzed Chan-Lam Coupling of NH-Diaryl Sulfondiimines[J]. ADVANCED SYNTHESIS & CATALYSIS,2022.
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| APA |
Wang，Yangyang,Meng，Tingting,Su，Shuaisong,Han，Limin,Zhu，Ning,&Jia，Tiezheng.(2022).Copper-Catalyzed Chan-Lam Coupling of NH-Diaryl Sulfondiimines.ADVANCED SYNTHESIS & CATALYSIS.
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| MLA |
Wang，Yangyang,et al."Copper-Catalyzed Chan-Lam Coupling of NH-Diaryl Sulfondiimines".ADVANCED SYNTHESIS & CATALYSIS (2022).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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