南方科技大学知识苑(SUSTech KC): Differential Activation of pERK1/2 and c-Fos Following Injury to Different Regions of Primary Sensory Neuron

题名	Differential Activation of pERK1/2 and c-Fos Following Injury to Different Regions of Primary Sensory Neuron
作者	Miao, Bei 1,2,3; Yao, Hongyu1,2 ; Chen, Peng1,2 ; Song, Xue-Jun1,2
通讯作者	Song, Xue-Jun
发表日期	2022-05-01
DOI	10.3390/life12050752
发表期刊	LIFE-BASEL 影响因子和分区
EISSN	2075-1729
卷号	12 期号:5
摘要	Nerve injury causes hyperexcitability of the dorsal root ganglion (DRG) and spinal dorsal horn (DH) neurons, which results in neuropathic pain. We have previously demonstrated that partial dorsal rhizotomy (PDR) produced less severe pain-like behavior than chronic constriction injury (CCI) or chronic compression of DRG (CCD) and did not enhance DRG neuronal excitability. However, the mechanisms underlying such discrepancy remain unclear. This study was designed to compare the activation of phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) in DRG and DH, and c-Fos in DH following treatments of CCI, CCD, and PDR. We confirmed that thermal hyperalgesia produced by PDR was less severe than that produced by CCI or CCD. We showed that pERK1/2 in DRG and DH was greatly activated by CCI or CCD, whereas PDR produced only transient and mild pERK1/2 activation. CCI, CCD, and PDR induced robust c-Fos expression in DH; nevertheless, c-Fos(+) neurons following PDR were much fewer than that following CCI or CCD. Blocking retrograde axonal transport by colchicine proximal to the CCI injury site diminished thermal hyperalgesia and inhibited pERK1/2 and c-Fos activation. These findings demonstrate that less severe pain-like behavior produced by PDR than CCI or CCD attributes to less activation of pERK1/2 and c-Fos. Such neurochemical activation partially relies on retrograde axonal transport of certain "injury signals" from the peripheral injured site to DRG somata.
关键词	pERK1 2 c-Fos partial dorsal rhizotomy (PDR) chronic compression of DRG (CCD) chronic constriction injury (CCI) axonal transport
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Foundation of Shenzhen Science and Technology Innovation Committee[JCYJ20200109141433384] ; Shenzhen Science and Technology Program[KQTD20200820113040070] ; National Natural Science Foundation of China[NSFC81971062]
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Microbiology
WOS类目	Biology ; Microbiology
WOS记录号	WOS:000804305500001
出版者	MDPI
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/335809
专题	南方科技大学医学院南方科技大学医学院_医学神经科学系
作者单位	1.Southern Univ Sci & Technol, Sch Med, Dept Med Neurosci, Shenzhen 518055, Peoples R China 2.Southern Univ Sci & Technol, SUSTech Ctr Pain Med, Sch Med, Shenzhen 518055, Peoples R China 3.Xuzhou Med Univ, Dept Gastroenterol, Affiliated Hosp, Xuzhou 221004, Jiangsu, Peoples R China
第一作者单位	南方科技大学医学院
通讯作者单位	南方科技大学医学院
第一作者的第一单位	南方科技大学医学院
推荐引用方式 GB/T 7714	Miao, Bei,Yao, Hongyu,Chen, Peng,et al. Differential Activation of pERK1/2 and c-Fos Following Injury to Different Regions of Primary Sensory Neuron[J]. LIFE-BASEL,2022,12(5).
APA	Miao, Bei,Yao, Hongyu,Chen, Peng,&Song, Xue-Jun.(2022).Differential Activation of pERK1/2 and c-Fos Following Injury to Different Regions of Primary Sensory Neuron.LIFE-BASEL,12(5).
MLA	Miao, Bei,et al."Differential Activation of pERK1/2 and c-Fos Following Injury to Different Regions of Primary Sensory Neuron".LIFE-BASEL 12.5(2022).