南方科技大学知识苑(SUSTech KC): Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs

题名	Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs
作者	Zhang, Shuxia 1; Liang, Yujie 2; Yao, Jun 3; Li, De-feng 3; Wang, Li-sheng 3
通讯作者	Wang, Li-sheng
发表日期	2022-05-23
DOI	10.3389/fphar.2022.833588
发表期刊	FRONTIERS IN PHARMACOLOGY 影响因子和分区
EISSN	1663-9812
卷号	13
摘要	Pyroptosis is a pro-inflammatory cell death executed by gasdermin family proteins that involve the formation of pores on cells, recognition of danger signals, and release of pro-inflammatory cytokines IL-1 beta and IL-18. Pyroptosis modulates mucosal innate immunity and enteropathogenic bacterial infection. Similarly, the gasdermin family has been reported to be involved in the defense of the intestinal epithelium against bacterial infection and in the regulation of intestinal inflammation. Pyroptosis initiates damage signals that activate multiple pathways to cause inflammation, which may be a potential cause of chronic intestinal inflammation. In this review, we discuss the impact of pyroptosis on inflammatory bowel disease (IBD), with a focus on the executive proteins of pyroptosis (GSDMB, GADMD, and GSDME) and IBD-related endogenous damage-associated molecular patterns (DAMPs) produced by pyroptosis.
关键词	IBD pyroptosis gasdermin intestinal pathogens HGMB1
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一
资助项目	Natural Science Foundation of Guangdong Province[2018A0303100024] ; Three Engineering Training Funds in Shenzhen["SYLY201718","SYJY201714","SYLY201801"] ; Technical Research and Development Project of Shenzhen["JCYJ20150403101028164","JCYC20170307100911479","JCYJ20190807145617113"] ; National Natural Science Foundation of China[81800489]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:000807885600001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计	被引频次[WOS]：21
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/336135
专题	南方科技大学医学院
作者单位	1.Southern Univ Sci & Technol, Shenzhen People Hosp, Sch Med, Shenzhen, Peoples R China 2.Shenzhen Kangning Hosp, Shenzhen, Peoples R China 3.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, Shenzhen, Peoples R China
第一作者单位	南方科技大学医学院
第一作者的第一单位	南方科技大学医学院
推荐引用方式 GB/T 7714	Zhang, Shuxia,Liang, Yujie,Yao, Jun,et al. Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs[J]. FRONTIERS IN PHARMACOLOGY,2022,13.
APA	Zhang, Shuxia,Liang, Yujie,Yao, Jun,Li, De-feng,&Wang, Li-sheng.(2022).Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs.FRONTIERS IN PHARMACOLOGY,13.
MLA	Zhang, Shuxia,et al."Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs".FRONTIERS IN PHARMACOLOGY 13(2022).