Photo-responsive NIR-II biomimetic nanomedicine for efficient cancer-targeted theranostics

Su, L.1; Liu, Y.1; Zhu, Y.1; Guo, F.1; Arkin, G.1; Lin, X.1; Xu, J.1; Xie, Z.2,3; Zhang, H.4,5,6

2022-06-01

10.1016/j.mtchem.2022.100879

Materials Today Chemistry   影响因子和分区

2468-5194

In pancreatic cancer, the special barrier system formed by a large number of stromal cells severely hinders drug penetration in deep tumor tissues, resulting in low treatment efficiency. Cell membrane protein-camouflaged liposomal nanomedicines have cancer cell targeting abilities, whereas near-infrared two-zone (NIR-II) fluorescence imaging can achieve deep tissue penetration due to its long light wavelength (1,000-1,70 0 nm). To combine the cell membrane-based biomimetic technology with NIR-II fluorescence imaging, we constructed a biomimetic nanomedicine (BLIPO-I/D) by camouflaging indocyanine green-doxorubicin (ICG-DOX) liposomes with SW1990 pancreatic cancer cell membrane. The nanomedicine exhibited light-controlled DOX release and high pancreatic cancer treatment efficiency in vitro and in vivo. BLIPO-I/D showed the ability of targeted delivery of a large number of liposomes to pancreatic tumor tissues through homologous targeting of SW1990 cell membranes, which increased the NIR-II fluorescence imaging intensity. Irradiation of the liposomes taken up by pancreatic tumor tissues with near-infrared light (808 nm) triggered the rapid release of DOX from the liposomes, induced the photothermal and photodynamic effects of ICG, which exerted anti-tumor effects. Therefore, the fabricated biomimetic liposomal nanomedicine BLIPO-I/D is expected to achieve precise theranostics of pancreatic cancer. (c) 2022 Elsevier Ltd. All rights reserved.

Biomimetic liposomal nanomedicine NIR-II fluorescence imaging Targeted theranostics Pancreatic cancer Light-controlled drug release

SCI ; EI

英语

第一 ; 通讯

Chemistry ; Materials Science

Chemistry, Multidisciplinary ; Materials Science, Multidisciplinary

WOS:000806169300010

ELSEVIER SCI LTD

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Med Ultrasound Engn Ctr, Dept Ultrasound,Shenzhen Peoples Hosp, Clin Med Coll 2,Jinan Univ,Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
2.Shenzhen Childrens Hosp, Inst Pediat, Shenzhen 518038, Guangdong, Peoples R China
3.Shenzhen Int Inst Biomed Res, Shenzhen 518116, Guangdong, Peoples R China
4.Minist Educ & Guangdong Prov, Key Lab Optoelect Devices & Syst, Coll Phys & Optoelect Engn, Shenzhen 518060, Peoples R China
5.Shenzhen Univ, Shenzhen Peoples Hosp 2, Otolaryngol Dept, Hlth Sci Ctr,Affiliated Hosp 1, Shenzhen 518060, Peoples R China
6.Shenzhen Univ, Shenzhen Peoples Hosp 2, Biobank, Hlth Sci Ctr,Affiliated Hosp 1, Shenzhen 518060, Peoples R China

Su, L.,Liu, Y.,Zhu, Y.,et al. Photo-responsive NIR-II biomimetic nanomedicine for efficient cancer-targeted theranostics[J]. Materials Today Chemistry,2022,24.

Su, L..,Liu, Y..,Zhu, Y..,Guo, F..,Arkin, G..,...&Zhang, H..(2022).Photo-responsive NIR-II biomimetic nanomedicine for efficient cancer-targeted theranostics.Materials Today Chemistry,24.

Su, L.,et al."Photo-responsive NIR-II biomimetic nanomedicine for efficient cancer-targeted theranostics".Materials Today Chemistry 24(2022).