Association of Dietary Phytosterols Intake and Survival of Esophageal Squamous Cell Carcinoma: A Prospective Cohort Study

Wang, Shuyi1,2; Zhao, Wenjing3; Li, Jun4; Hu, Peng2; Zhao, Yue2; Tse, Lap-Ah5; Lu, Jiahai2; Ren, Zefang2; Xing, Xiangbing6; Liu, Xudong1

2022-06-01

10.1080/01635581.2022.2085311

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL   影响因子和分区

0163-5581

1532-7914

Background The association of dietary phytosterols intake with survival of esophageal squamous cell carcinoma (ESCC) remains unclear. This study was to examine the effect of dietary phytosterols intake on ESCC survival in a Chinese rural population. Methods A total of 942 incident ESCC patients diagnosed between 2011 and 2013 in Yanting area were followed up until March 1(st), 2020. Dietary intake five years before ESCC diagnosis was collected using a food frequency questionnaire. The outcome of interest was all-cause mortality. Cox proportional hazards regression model was used to estimate hazard ratio (HR) and 95% confidence intervals (CI). Results When comparing the highest with lowest intake quartiles, intake of five specific and total phytosterols was not significantly associated with risk of death after adjustment for covariates, the adjusted HR (95% CI) for beta-sitosterol, campesterol, stigmasterol, beta-sitostanol, campestanol and total phytosterols was 0.90 (95% CI: 0.70-1.16), 0.92 (95% CI: 0.71-1.19), 0.86 (95% CI: 0.66-1.12), 0.93 (95% CI: 0.73-1.20), 0.94 (95% CI: 0.72-1.21), 0.89 (95% CI: 0.69-1.15), respectively. Conclusion This study does not find any association between pre-diagnostic phytosterols intake and risk of all-cause mortality among ESCC patients. Further research is required to determine the effect of post-diagnostic phytosterols intake on ESCC survival.

SCI

英语

其他

Guangdong Basic and Applied Basic Research Foundation[2019A1515011599] ; Science and Technology Program of Guangzhou City[202102080404] ; World Cancer Research Fund[2010/240] ; National Key R&D Program of China[2018YFE0208000]

Oncology ; Nutrition & Dietetics

Oncology ; Nutrition & Dietetics

WOS:000807615800001

ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD

CLINICAL MEDICINE

Web of Science

1.Guangdong Pharmaceut Univ, Sch Publ Hlth, 283 Jianghai Ave, Guangzhou 510310, Peoples R China
2.Sun Yat Sen Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou, Peoples R China
3.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China
4.Yanting Canc Hosp, Dept Canc Prevent & Treatment, Mianyang, Sichuan, Peoples R China
5.Chinese Univ Hong Kong, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
6.Sun Yat Sen Univ, Dept Gastroenterol, Affiliated Hosp 1, Guangzhou, Peoples R China

Wang, Shuyi,Zhao, Wenjing,Li, Jun,et al. Association of Dietary Phytosterols Intake and Survival of Esophageal Squamous Cell Carcinoma: A Prospective Cohort Study[J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL,2022.

Wang, Shuyi.,Zhao, Wenjing.,Li, Jun.,Hu, Peng.,Zhao, Yue.,...&Liu, Xudong.(2022).Association of Dietary Phytosterols Intake and Survival of Esophageal Squamous Cell Carcinoma: A Prospective Cohort Study.NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL.

Wang, Shuyi,et al."Association of Dietary Phytosterols Intake and Survival of Esophageal Squamous Cell Carcinoma: A Prospective Cohort Study".NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2022).