南方科技大学知识苑(SUSTech KC): The KMT1A/TIMP3/PI3K/AKT circuit regulates tumor growth in cervical cancer

题名	The KMT1A/TIMP3/PI3K/AKT circuit regulates tumor growth in cervical cancer
作者	Yang，Degui 1; Fan，Leilei 1; Song，Zhenkun 1; Fang，Su 1; Huang，Miaoyu 1; Chen，Piji 2
通讯作者	Chen，Piji
发表日期	2022-09-01
DOI	10.1016/j.repbio.2022.100644
发表期刊	Reproductive Biology 影响因子和分区
ISSN	1642-431X
EISSN	2300-732X
卷号	22 期号:3
摘要	The epigenetic mechanism of tissue inhibitor of metalloproteinase 3 (TIMP3), a well-known tumor suppressor, in cervical cancer (CC) is still unclear. Integrated GEO database, protein interaction network, and a pan-cancer analysis revealed a KMT1A/TIMP3 axis in CC. KMT1A was highly expressed, and TIMP3 was poorly expressed in CC tissues and cells. KMT1A inhibited the activity of TIMP3. Silencing of KMT1A hampered the proliferation, migration, invasion, tumorigenesis and metastases of CC cells in vivo, and increased the apoptosis of cells. TIMP3 downregulation promoted the malignant phenotype and in vivo tumorigenesis and metastasis of CC cells. KMT1A downregulation impaired PI3K/AKT pathway in cells, while TIMP3 silencing promoted PI3K/AKT pathway activity. We propose a novel perspective that KMT1A involves in the growth and metastases via the TIMP3/PI3K/AKT axis in CC. In summary, our study identified a vital role played by KMT1A in the development of CC and the epigenetic mechanism, indicating that targeting KMT1A-related pathways could be conducive to the therapies for CC.
关键词	Cervical cancer Histone methyltransferase KMT1A PI3K/AKT pathway TIMP3
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	通讯
WOS研究方向	Reproductive Biology
WOS类目	Reproductive Biology
WOS记录号	WOS:000811864900002
出版者	ELSEVIER
Scopus记录号	2-s2.0-85131139471
来源库	Scopus
引用统计	被引频次[WOS]：7
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/336213
专题	南方科技大学南方科技大学第一附属医院
作者单位	1.Department of Gynecology,Shenzhen People's Hospital,Shenzhen,Guangdong,518100,China 2.Department of Clinical Laboratory,Yantian People's Hospital of Southern University of Science and Technology,Shenzhen,Guangdong,518083,China
通讯作者单位	南方科技大学
推荐引用方式 GB/T 7714	Yang，Degui,Fan，Leilei,Song，Zhenkun,et al. The KMT1A/TIMP3/PI3K/AKT circuit regulates tumor growth in cervical cancer[J]. Reproductive Biology,2022,22(3).
APA	Yang，Degui,Fan，Leilei,Song，Zhenkun,Fang，Su,Huang，Miaoyu,&Chen，Piji.(2022).The KMT1A/TIMP3/PI3K/AKT circuit regulates tumor growth in cervical cancer.Reproductive Biology,22(3).
MLA	Yang，Degui,et al."The KMT1A/TIMP3/PI3K/AKT circuit regulates tumor growth in cervical cancer".Reproductive Biology 22.3(2022).