Infant Skin Friendly Adhesive Hydrogel Patch Activated at Body Temperature for Bioelectronics Securing and Diabetic Wound Healing

Jiang，Yanan1; Zhang，Xin1; Zhang，Wei1; Wang，Menghao2; Yan，Liwei1; Wang，Kefeng3; Han，Lu4; Lu，Xiong1

2022

10.1021/acsnano.2c00662

ACS Nano   影响因子和分区

1936-0851

1936-086X

Adhesive-caused injury is a great threat for infants with premature skin or diabetic patients with fragile skin because extra-strong adhesion might incur pain, inflammation, and exacerbate trauma upon removal. Herein, we present a skin-friendly adhesive hydrogel patch based on protein-polyphenol complexation strategy, which leads to a thermoresponsive network sensitive to body temperature. The adhesion of the hydrogel is smartly activated after contacting with warm skin, whereas the painless detachment is easily realized by placing an ice bag on the surface of the hydrogel. The hydrogel exhibits an immunomodulatory performance that prevents irritation and allergic reactions during long-period contact with the skin. Thus, the hydrogel patch works as a conformable and nonirritating interface to guarantee nondestructively securing bioelectronics on infant skin for healthcare. Furthermore, the hydrogel patch provides gentle adhesion to wounded skin and provides a favorable environment to speed up the healing process for managing diabetic wounds.

adhesive hydrogel detachable hydrogel diabetic wound polyphenol chemistry wound dressing

EI

英语

NI论文

其他

20222312187319

Adhesion ; Adhesives ; Physiology

Biology:461.9 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Materials Science:951

2-s2.0-85131120716

Scopus

1.School of Materials Science and Engineering,Key Lab of Advanced Technologies of Materials,Yibin Institute of Southwest Jiaotong University,Chengdu,610031,China
2.Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China
3.National Engineering Research Center for Biomaterials,Sichuan University,Chengdu,610064,China
4.School of Medicine and Pharmaceutics,Laboratory for Marine Drugs and Bioproducts,Ocean University of China,Pilot National Laboratory for Marine Science and Technology,Qingdao,266003,China

Jiang，Yanan,Zhang，Xin,Zhang，Wei,et al. Infant Skin Friendly Adhesive Hydrogel Patch Activated at Body Temperature for Bioelectronics Securing and Diabetic Wound Healing[J]. ACS Nano,2022,16:8662-8676.

Jiang，Yanan.,Zhang，Xin.,Zhang，Wei.,Wang，Menghao.,Yan，Liwei.,...&Lu，Xiong.(2022).Infant Skin Friendly Adhesive Hydrogel Patch Activated at Body Temperature for Bioelectronics Securing and Diabetic Wound Healing.ACS Nano,16,8662-8676.

Jiang，Yanan,et al."Infant Skin Friendly Adhesive Hydrogel Patch Activated at Body Temperature for Bioelectronics Securing and Diabetic Wound Healing".ACS Nano 16(2022):8662-8676.