Electrophysiological Characterization of Substantia Nigra Pars Reticulata in Anesthetized Rats

Liu，Xinrui1; Zhang，Qianwen1; Wang，Ying2; Chen，Fujun1,3

2022

10.1007/s12204-022-2420-y

Journal of Shanghai Jiaotong University (Science)   影响因子和分区

1007-1172

1995-8188

The substantia nigra pars reticulate (SNr), which plays a pivotal role in motor control, is the key structure in integrating information for cortex, basal ganglia and thalamus. Abnormal gait and posture deficits can be reversed by SNr deep brain stimulation (DBS) in certain Parkinson’s disease cases. However, functional characterization of SNr, which is the key for the optimization of DBS effect, remains elusive. In current study, we recorded extracellular single unit in SNr of urethane anesthetized rats. We have found that urethane can induce slow delta and theta oscillations in SNr local field potential. The high gamma oscillation observed is positively correlated with the occurrence of action potential. The putative GABAergic neurons have a mean firing rate of (20.82 ± 2.04) Hz, of which 65.2% display a regular firing pattern and 34.8% show irregular firing. Our results demonstrated the heterogeneous property of SNr and provided possible theoretical basis for promoting the next generation of DBS electrode design and optimization of clinical DBS parameters.

A electrophysiology firing regularity local field potential Q 424 substantia nigra pars reticulate (SNr)

EI

英语

其他

20222112130071

Esters ; Neurosurgery ; Rats

Biomedical Engineering:461.1 ; Medicine and Pharmacology:461.6 ; Organic Compounds:804.1

2-s2.0-85130111170

Scopus

1.Bio-X Institutes,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders,Ministry of Education,Shanghai Jiao Tong University,Shanghai,200240,China
2.Core Research Facilities,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
3.Exercise Health and Technology Center,Department of Physical Education,Shanghai Jiao Tong University,Shanghai,200240,China

Liu，Xinrui,Zhang，Qianwen,Wang，Ying,et al. Electrophysiological Characterization of Substantia Nigra Pars Reticulata in Anesthetized Rats[J]. Journal of Shanghai Jiaotong University (Science),2022,27:505-511.

Liu，Xinrui,Zhang，Qianwen,Wang，Ying,&Chen，Fujun.(2022).Electrophysiological Characterization of Substantia Nigra Pars Reticulata in Anesthetized Rats.Journal of Shanghai Jiaotong University (Science),27,505-511.

Liu，Xinrui,et al."Electrophysiological Characterization of Substantia Nigra Pars Reticulata in Anesthetized Rats".Journal of Shanghai Jiaotong University (Science) 27(2022):505-511.