一种手性二氢黄酮类化合物及其衍生物的制备方法和应用

汪君; 熊东路; 周文茜; 陆志武

汪君

南方科技大学

南方科技大学

518000 广东省深圳市南山区西丽学苑大道1088号

南方科技大学

518000 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)

南方科技大学

518000 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)

CN201710379364.9

2017-05-25

CN106977486B

2019-09-24

2019-09-24

授权

2019-09-24

授权发明

第一

本发明提供一种手性二氢黄酮类化合物及其衍生物及其制备方法和应用，所述方法为在非贵金属硅氢催化剂催化下式I所示原料发生不对称氢转移反应得到式II所示手性二氢黄酮类化合物及其衍生物，本发明的制备方法选用廉价的非贵金属催化剂，成本低，环境影响较小，选用硅烷作氢源，操作简便安全，反应步骤少，原料易得，反应条件温和，对应选择性达90％以上，甚至高达94％以上，收率高，产物收率可以达到80％以上，大大提高了产物的对应选择性和收率，制备得到的手性二氢黄酮类化合物及其衍生物用途广泛。

The invention provides a preparation method and application of a chiral dihydroflavone compound and derivatives thereof. The preparation method includes: a raw material as shown in formula I is allowed to have asymmetric hydrogen transfer reaction under the catalyzing of a non-noble-metal silicon-hydrogen catalyst to obtain the chiral dihydroflavone compound and derivatives thereof as shown in formula II. The preparation method has the advantages that cheap non-noble-metal silicon-hydrogen catalyst is used, low cost and low influence on environments are achieved, silane is used as the hydrogen source, operation simpleness and safety are achieved, reaction steps are few, raw materials are easy to obtain, reaction conditions are mild, enanioselectivity reaches above 90% and even reaches up to more than 94%, high yield is achieved, the yield can reach above 80%, the enanioselectivity and yield of the product are increased greatly, and the prepared chiral dihydroflavone compound and derivatives thereof are widely applicable.

C07D311/74 ; C07D335/06 ; C07D405/04 ; B01J21/06 ; B01J23/06 ; B01J23/14 ; B01J23/745 ; B01J23/72 ; B01J23/75 ; B01J23/755

（+PATENT GRANT）[2019-09-24][CN]

1

1

巩克栋

北京品源专利代理有限公司

PatSnap

汪君,熊东路,周文茜,等. 一种手性二氢黄酮类化合物及其衍生物的制备方法和应用[P]. 2019-09-24.