抗原、核酸、表达载体、抗原呈递细胞和细胞毒性T细胞及其应用

本发明涉及一种抗原、核酸、表达载体、抗原呈递细胞和细胞毒性T细胞及其应用。该抗原包括下述多肽片段或与下述多肽片段具有至少80％的序列同一性的多肽片段：A‑X1‑S‑K‑W‑V‑G‑K‑X2，其中，X1是L或M，X2是V、L或I。上述抗原可以诱导产生对肝癌细胞具有特异性杀伤的细胞毒性T细胞。

The invention relates to an antigen, a nucleic acid, an expression vector, an antigen presenting cell, a cytotoxic T cell and application of the cytotoxic T cell. The antigen comprises the following polypeptide fragment or a polypeptide fragment having at least 80% sequence identity with the following polypeptide fragment: A-X1-S-K-W-V-G-K-X2, wherein X1 is L or M, and X2 is V, L or I. The antigen can induce the generation of the cytotoxic T cell with the specific killing effect on liver cancer cell.